Polk MGI Mouse Gene Detail - MGI:1349767 - polymerase (DNA directed), kappa

Symbol

Polk
Name

polymerase (DNA directed), kappa
Synonyms

Dinb1

Feature Type

protein coding gene
IDs

MGI:1349767
NCBI Gene: 27015
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:96617198-96679087 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 50.56 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

1875 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349767	protein coding gene	Chr13:96617195-96679087 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020850	protein coding gene	Chr13:98016847-98083570 (-)
A/J	MGP_AJ_G0020804	protein coding gene	Chr13:94326118-94388965 (-)
AKR/J	MGP_AKRJ_G0020778	protein coding gene	Chr13:97208119-97273978 (-)
BALB/cJ	MGP_BALBcJ_G0020801	protein coding gene	Chr13:95026422-95088151 (-)
C3H/HeJ	MGP_C3HHeJ_G0020594	protein coding gene	Chr13:96903497-96969522 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021236	protein coding gene	Chr13:100990712-101056604 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018805	protein coding gene	Chr13:90127245-90190291 (-)
CAST/EiJ	MGP_CASTEiJ_G0020112	protein coding gene	Chr13:96229362-96294968 (-)
CBA/J	MGP_CBAJ_G0020553	protein coding gene	Chr13:104992963-105060422 (-)
DBA/2J	MGP_DBA2J_G0020678	protein coding gene	Chr13:94103247-94165637 (-)
FVB/NJ	MGP_FVBNJ_G0020659	protein coding gene	Chr13:92865488-92928450 (-)
LP/J	MGP_LPJ_G0020753	protein coding gene	Chr13:98153456-98217983 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020687	protein coding gene	Chr13:105374665-105438518 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021277	protein coding gene	Chr13:96627119-96699046 (-)
PWK/PhJ	MGP_PWKPhJ_G0019864	protein coding gene	Chr13:92887251-92950344 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019688	protein coding gene	Chr13:92917224-92984170 (-)
WSB/EiJ	MGP_WSBEiJ_G0020169	protein coding gene	Chr13:97111460-97176926 (-)

Human Ortholog

POLK, DNA polymerase kappa

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLK, DNA polymerase kappa
Synonyms

DINB1, DINP, POLQ
Links

HGNC:9183

NCBI Gene ID: 51426

neXtProt AC: NX_Q9UBT6

UniProt: Q9UBT6
Chr Location

5q13.3; chr5:75510774-75609991 (+) GRCh38

MGI Vertebrate Homology

Polk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLK
Protein SuperFamily

DPol_eta
Gene Tree

Polk

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

2
Gene trapped

17
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

65 strains or lines available

Homozygous mutation of this gene that results in a truncated transcript results in a higher rate of spontaneous germline expanded simple tandem repeat mutations. Homozyogus null mice exhibit normal immunoglobulin gene somatic hypermutation.

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

37
cDNA Data

37
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polk

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All Sequences

104
RefSeq

22
UniProt

16
CCDS

CCDS26704.1, CCDS84053.1, CCDS88502.1, CCDS88503.1, CCDS88504.1

Ensembl

ENSMUSG00000021668 (Evidence)
NCBI Gene

27015

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021668	Ensembl Gene Model \| MGI Sequence Detail	61890	C57BL/6J	± kb
transcript	ENSMUST00000022172	Ensembl \| MGI Sequence Detail	4225	Not Applicable
polypeptide	ENSMUSP00000022172	Ensembl \| MGI Sequence Detail	852	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000012977 DNA polymerase kappa

(term hierarchy)
PDB

2LSJ, 4FJO, 6C59, 6C8C
EC

2.7.7.7
InterPro Domains

IPR022880 DNA polymerase IV

IPR050116 DNA polymerase type-Y

IPR024728 DNA polymerase type-Y, HhH motif

IPR017961 DNA polymerase, Y-family, little finger domain

IPR036775 DNA polymerase, Y-family, little finger domain superfamily

IPR043502 DNA/RNA polymerase superfamily

IPR006642 Rad18, zinc finger UBZ4-type

IPR043128 Reverse transcriptase/Diguanylate cyclase domain

IPR001126 UmuC domain

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All nucleic 41

cDNA 37

Primer pair 4

Microarray probesets 5

Summaries

All 54

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 18
Earliest

J:58083 Gerlach VL, et al., Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11922-7
Latest

J:348075 Shah P, et al., Primordial germ cell DNA demethylation and development require DNA translesion synthesis. Nat Commun. 2024 May 3;15(1):3734

TSS for Polk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123566	Chr13:96679062-96679075 (-)	18 bp
Tssr123565	Chr13:96678987-96679031 (-)	78 bp
Tssr123564	Chr13:96678942-96678953 (-)	139 bp
Tssr123563	Chr13:96678842-96678853 (-)	239 bp
Tssr123562	Chr13:96678830-96678841 (-)	251 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24