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Asns Gene Detail
Summary
  • Symbol
    Asns
  • Name
    asparagine synthetase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350929
    NCBI Gene: 27053
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:7675169-7693209 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 3.31 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    880 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350929
 protein coding gene Chr6:7675169-7693254 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030444
 protein coding gene Chr6:4571823-4589701 (-)
A/J MGP_AJ_G0030417
 protein coding gene Chr6:4432026-4450094 (-)
AKR/J MGP_AKRJ_G0030344
 protein coding gene Chr6:4595297-4613363 (-)
BALB/cJ MGP_BALBcJ_G0030426
 protein coding gene Chr6:4391542-4413765 (-)
C3H/HeJ MGP_C3HHeJ_G0030140
 protein coding gene Chr6:4482341-4500344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030881
 protein coding gene Chr6:4717874-4736025 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028092
 protein coding gene Chr6:3976333-3994136 (-)
CAST/EiJ MGP_CASTEiJ_G0029541
 protein coding gene Chr6:4469938-4488788 (-)
CBA/J MGP_CBAJ_G0030118
 protein coding gene Chr6:4827314-4846116 (-)
DBA/2J MGP_DBA2J_G0030262
 protein coding gene Chr6:4384445-4402706 (-)
FVB/NJ MGP_FVBNJ_G0030216
 protein coding gene Chr6:4354215-4372130 (-)
LP/J MGP_LPJ_G0030349
 protein coding gene Chr6:4552185-4573206 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030252
 protein coding gene Chr6:4917713-4937215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030911
 protein coding gene Chr6:4494224-4513523 (-)
PWK/PhJ MGP_PWKPhJ_G0029256
 protein coding gene Chr6:4264163-4282579 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029092
 protein coding gene Chr6:4520115-4537830 (-)
WSB/EiJ MGP_WSBEiJ_G0029618
 protein coding gene Chr6:4470622-4488425 (-)



Homology
more
  • Human Ortholog
    ASNS, asparagine synthetase (glutamine-hydrolyzing)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASNS, asparagine synthetase (glutamine-hydrolyzing)
  • Synonyms
    ASNSD, TS11
  • Links
    NCBI Gene ID: 440
    neXtProt AC: NX_P08243
    UniProt: P08243

  • Chr Location
    7q21.3; chr7:97851677-97928441 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomophic allele exhibit structural brain abnormalities, including enlarged ventricles and reduced cortical thickness, and deficits in short- and long-term memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1101
  • Tissues
    129
  • cDNA Data
    214
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27053 NCBI Gene Model | MGI Sequence Detail 18041 C57BL/6J ±  kb
    transcript NM_001410605 RefSeq | MGI Sequence Detail 2243 C57BL/6  
    polypeptide Q61024 UniProt | EBI | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 218
      cDNA 214
      Primer pair 3
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:58768 Goodwin L, et al., Patterns of expression of asparagine synthetase mRNA in various human leukemic and carcinoma cell lines. Proc Am Soc Human Genet. 1994;55:325 (Abstr.)
    • Latest
      J:353791 Xu L, et al., Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory