Tlx3 MGI Mouse Gene Detail - MGI:1351209 - T cell leukemia, homeobox 3

Symbol

Tlx3
Name

T cell leukemia, homeobox 3
Synonyms

Hox11l2, Rnx, Tlx1l2

Feature Type

protein coding gene
IDs

MGI:1351209
NCBI Gene: 27140
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:33150752-33153589 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 19.21 cM, cytoband A5
Mapping Data

1 experiment

SNPs within 2kb

102 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351209	protein coding gene	Chr11:33150748-33158588 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018142	protein coding gene	Chr11:31492739-31495576 (-)
A/J	MGP_AJ_G0018115	protein coding gene	Chr11:30289819-30292662 (-)
AKR/J	MGP_AKRJ_G0018079	protein coding gene	Chr11:31236931-31239770 (-)
BALB/cJ	MGP_BALBcJ_G0018084	protein coding gene	Chr11:30462526-30465344 (-)
C3H/HeJ	MGP_C3HHeJ_G0017897	protein coding gene	Chr11:31177875-31180720 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018538	protein coding gene	Chr11:32508219-32511056 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016193	protein coding gene	Chr11:28790765-28793575 (-)
CAST/EiJ	MGP_CASTEiJ_G0017461	protein coding gene	Chr11:31250260-31253124 (-)
CBA/J	MGP_CBAJ_G0017870	protein coding gene	Chr11:34068961-34071800 (-)
DBA/2J	MGP_DBA2J_G0017980	protein coding gene	Chr11:30057313-30060156 (-)
FVB/NJ	MGP_FVBNJ_G0017974	protein coding gene	Chr11:29887774-29890619 (-)
LP/J	MGP_LPJ_G0018052	protein coding gene	Chr11:31751361-31754179 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017998	protein coding gene	Chr11:35016218-35019067 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018577	protein coding gene	Chr11:31378858-31381678 (-)
PWK/PhJ	MGP_PWKPhJ_G0017242	protein coding gene	Chr11:30238274-30241122 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017034	protein coding gene	Chr11:31098177-31101020 (-)
WSB/EiJ	MGP_WSBEiJ_G0017510	protein coding gene	Chr11:31001606-31004452 (-)

Human Ortholog

TLX3, T cell leukemia homeobox 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TLX3, T cell leukemia homeobox 3
Synonyms

HOX11L2, RNX
Links

HGNC:13532

NCBI Gene ID: 30012

neXtProt AC: NX_O43711

UniProt: O43711
Chr Location

5q35.1; chr5:171309248-171312139 (+) GRCh38

MGI Vertebrate Homology

Tlx3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TLX3
Gene Tree

Tlx3

Diseases

1 with Tlx3 mouse models

Human Disease

Mouse Models

congenital central hypoventilation syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

16 phenotypes from 2 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Tlx3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice die within 1 day of birth due to a central respiratory failure that resembles human congenital central hypoventilation syndrome. Mice homozygous for an ENU-induced allele exhibit uncoordinated movements.

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All GO Annotations

23
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

897
Tissues

132
cDNA Data

12
Literature Summary

85

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tlx3

ZFIN tlx3b

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All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS24533.1

Ensembl

ENSMUSG00000040610 (Evidence)
NCBI Gene

27140

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040610	Ensembl Gene Model \| MGI Sequence Detail	2838	C57BL/6J	± kb
transcript	ENSMUST00000037746	Ensembl \| MGI Sequence Detail	1533	Not Applicable
polypeptide	ENSMUSP00000047457	Ensembl \| MGI Sequence Detail	291	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016385 T-cell leukemia homeobox protein 3

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR042247 T-cell leukemia homeobox protein 1/2/3

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All nucleic 22

Genomic 3

cDNA 12

Primer pair 1

Other 6

Microarray probesets 3

Summaries

All 126

Developmental Gene Expression 85

Diseases 2

Gene Ontology 13

Phenotypes 28
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:359270 Parvathy S, et al., TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism. iScience. 2024 Dec 20;27(12):111260

TSS for Tlx3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107328	Chr11:33153600-33153611 (-)	-17 bp
Tssr107327	Chr11:33153589-33153599 (-)	-5 bp
Tssr107326	Chr11:33153563-33153583 (-)	16 bp
Tssr107325	Chr11:33153551-33153561 (-)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24