Nrk MGI Mouse Gene Detail - MGI:1351326

Symbol

Nrk
Name

Nik related kinase
Synonyms

Nesk

Feature Type

protein coding gene
IDs

MGI:1351326
NCBI Gene: 27206
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

ChrX:137815179-137911281 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 61.15 cM
Mapping Data

3 experiments

SNPs within 2kb

1916 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351326	protein coding gene	ChrX:137814980-137911281 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036117	protein coding gene	ChrX:136381922-136486165 (+)
A/J	MGP_AJ_G0036096	protein coding gene	ChrX:135774040-135871791 (+)
AKR/J	MGP_AKRJ_G0036020	protein coding gene	ChrX:140139605-140241287 (+)
BALB/cJ	MGP_BALBcJ_G0036085	protein coding gene	ChrX:134134220-134231108 (+)
C3H/HeJ	MGP_C3HHeJ_G0035794	protein coding gene	ChrX:136419454-136518676 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036610	protein coding gene	ChrX:140420125-140518930 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033435	protein coding gene	ChrX:127572328-127672086 (+)
CAST/EiJ	MGP_CASTEiJ_G0035085	protein coding gene	ChrX:117202840-117321463 (+)
CBA/J	MGP_CBAJ_G0035771	protein coding gene	ChrX:144666983-144769254 (+)
DBA/2J	MGP_DBA2J_G0035928	protein coding gene	ChrX:134984532-135083789 (+)
FVB/NJ	MGP_FVBNJ_G0035862	protein coding gene	ChrX:134216639-134311731 (+)
LP/J	MGP_LPJ_G0036020	protein coding gene	ChrX:137340069-137445658 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035899	protein coding gene	ChrX:152154369-152292294 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036646	protein coding gene	ChrX:135725649-135822262 (+)
PWK/PhJ	MGP_PWKPhJ_G0034778	protein coding gene	ChrX:114176306-114274109 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034605	protein coding gene	ChrX:117769523-117866685 (+)
WSB/EiJ	MGP_WSBEiJ_G0035220	protein coding gene	ChrX:134023938-134123922 (+)

Human Ortholog

NRK, Nik related kinase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRK, Nik related kinase
Synonyms

NESK
Links

HGNC:25391

NCBI Gene ID: 203447

neXtProt AC: NX_Q7Z2Y5

UniProt: Q7Z2Y5
Chr Location

Xq22.3; chrX:105821786-105958610 (+) GRCh38

MGI Vertebrate Homology

Nrk stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NRK
Gene Tree

Nrk

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
3 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice nullizygous for a knock-out allele exhibit partial lethality during delivery associated with enlarged placental and spongiotrophoblast layer and enduce dystocia in birthing dams.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1011
Tissues

197
cDNA Data

23
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

54
RefSeq

4
UniProt

4
CCDS

CCDS41143.1

Ensembl

ENSMUSG00000052854 (Evidence)
NCBI Gene

27206

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052854	Ensembl Gene Model \| MGI Sequence Detail	96103	C57BL/6J	± kb
transcript	ENSMUST00000113052	Ensembl \| MGI Sequence Detail	8043	Not Applicable
polypeptide	ENSMUSP00000108675	Ensembl \| MGI Sequence Detail	1455	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011430 Nik-related protein kinase

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR001180 Citron homology (CNH) domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR051700 STE20 Ser/Thr Protein Kinase
GlyGen

Q9R0G8 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 25

cDNA 23

Primer pair 2

Microarray probesets 6

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MGI:2142415, MGI:2147816, MGI:2147855, MGI:2147979, MGI:2148017

Summaries

All 37

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 7
Earliest

J:58547 Kanai-Azuma M, et al., Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Mech Dev. 1999 Dec;89(1-2):155-9
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Nrk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162120	ChrX:137815141-137815152 (+)	-32 bp
Tssr162121	ChrX:137815171-137815187 (+)	0 bp
Tssr162122	ChrX:137815194-137815209 (+)	23 bp
Tssr5684	ChrX:137821086-137821087 (+)	5,908 bp
Tssr162123	ChrX:137837072-137837078 (+)	21,896 bp
Tssr162124	ChrX:137876241-137876288 (+)	61,086 bp
Tssr162125	ChrX:137886240-137886251 (+)	71,067 bp
Tssr162126	ChrX:137900422-137900437 (+)	85,251 bp
Tssr162127	ChrX:137908415-137908426 (+)	93,242 bp
Tssr162128	ChrX:137909489-137909509 (+)	94,320 bp
Tssr162129	ChrX:137909806-137909826 (+)	94,637 bp
Tssr162130	ChrX:137910399-137910410 (+)	95,226 bp
Tssr162131	ChrX:137910541-137910552 (+)	95,368 bp
Tssr162132	ChrX:137910675-137910678 (+)	95,498 bp
Tssr162133	ChrX:137910685-137910690 (+)	95,509 bp
Tssr162134	ChrX:137910793-137910803 (+)	95,619 bp
Tssr162135	ChrX:137910817-137910840 (+)	95,650 bp
Tssr162136	ChrX:137910846-137910862 (+)	95,675 bp
Tssr162137	ChrX:137910868-137910893 (+)	95,702 bp
Tssr162138	ChrX:137910894-137910982 (+)	95,759 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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