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Syn3 Gene Detail
Summary
  • Symbol
    Syn3
  • Name
    synapsin III
  • Synonyms
    Synapsin IIIa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351334
    NCBI Gene: 27204
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:85890989-86334760 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.95 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11693 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351334
 protein coding gene Chr10:85884610-86336730 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017608
 protein coding gene Chr10:87002632-87463197 (-)
A/J MGP_AJ_G0017588
 protein coding gene Chr10:84105223-84546857 (-)
AKR/J MGP_AKRJ_G0017548
 protein coding gene Chr10:86459114-86910745 (-)
BALB/cJ MGP_BALBcJ_G0017551
 protein coding gene Chr10:84335245-84773344 (-)
C3H/HeJ MGP_C3HHeJ_G0017374
 protein coding gene Chr10:86484407-86950990 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018008
 protein coding gene Chr10:89958852-90403046 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015692
 protein coding gene Chr10:79938083-80375670 (-)
CAST/EiJ MGP_CASTEiJ_G0016940
 protein coding gene Chr10:86354553-86806886 (-)
CBA/J MGP_CBAJ_G0017343
 protein coding gene Chr10:93674689-94134891 (-)
DBA/2J MGP_DBA2J_G0017450
 protein coding gene Chr10:83217837-83659233 (-)
FVB/NJ MGP_FVBNJ_G0017443
 protein coding gene Chr10:82486705-82931049 (-)
LP/J MGP_LPJ_G0017522
 protein coding gene Chr10:87679989-88134254 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017471
 protein coding gene Chr10:95305399-95759769 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018045
 protein coding gene Chr10:86330500-86788917 (-)
PWK/PhJ MGP_PWKPhJ_G0016721
 protein coding gene Chr10:83227148-83668934 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016510
 protein coding gene Chr10:84980141-85437747 (-)
WSB/EiJ MGP_WSBEiJ_G0016998
 protein coding gene Chr10:86295686-86764751 (-)



Homology
more
  • Human Ortholog
    SYN3, synapsin III
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYN3, synapsin III
  • Links
    NCBI Gene ID: 8224
    neXtProt AC: NX_O14994
    UniProt: O14994

  • Chr Location
    22q12.3; chr22:32507820-33058381 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Syn3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display altered neurotransmitter release, reduced synaptic depression, and a specific delay in early axon outgrowth in cultured hippocampal neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    42
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059602 Ensembl Gene Model | MGI Sequence Detail 443772 C57BL/6J ±  kb
    transcript ENSMUST00000120638 Ensembl | MGI Sequence Detail 2360 Not Applicable  
    polypeptide ENSMUSP00000113720 Ensembl | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 2
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 7
      Phenotypes 46
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350561 Bruentgens F, et al., The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal Mossy Fibers in Male Mice. eNeuro. 2024 Jul;11(7):ENEURO.0330-23.2024
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory