Ddx24 MGI Mouse Gene Detail - MGI:1351337

Symbol

Ddx24
Name

DEAD box helicase 24
Synonyms

1700055J08Rik, 2510027P10Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24

Feature Type

protein coding gene
IDs

MGI:1351337
NCBI Gene: 27225
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:103374241-103392089 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 52.92 cM
Mapping Data

2 experiments

SNPs within 2kb

477 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351337	protein coding gene	Chr12:103374235-103392106 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020049	protein coding gene	Chr12:105087186-105105077 (-)
A/J	MGP_AJ_G0020005	protein coding gene	Chr12:101048630-101066521 (-)
AKR/J	MGP_AKRJ_G0019981	protein coding gene	Chr12:103898083-103915974 (-)
BALB/cJ	MGP_BALBcJ_G0019991	protein coding gene	Chr12:101404571-101422462 (-)
C3H/HeJ	MGP_C3HHeJ_G0019793	protein coding gene	Chr12:104390700-104408591 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020440	protein coding gene	Chr12:108353117-108371008 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018053	protein coding gene	Chr12:98090034-98108789 (-)
CAST/EiJ	MGP_CASTEiJ_G0019339	protein coding gene	Chr12:99244294-99262194 (-)
CBA/J	MGP_CBAJ_G0019765	protein coding gene	Chr12:112380558-112398449 (-)
DBA/2J	MGP_DBA2J_G0019876	protein coding gene	Chr12:100570550-100590734 (-)
FVB/NJ	MGP_FVBNJ_G0019865	protein coding gene	Chr12:99304333-99322224 (-)
LP/J	MGP_LPJ_G0019952	protein coding gene	Chr12:104934395-104952286 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019905	protein coding gene	Chr12:115835927-115853813 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020469	protein coding gene	Chr12:103435105-103452997 (-)
PWK/PhJ	MGP_PWKPhJ_G0019102	protein coding gene	Chr12:95132369-95150261 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018898	protein coding gene	Chr12:97637130-97668214 (-)
WSB/EiJ	MGP_WSBEiJ_G0019393	protein coding gene	Chr12:104320941-104338832 (-)

Human Ortholog

DDX24, DEAD-box helicase 24

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX24, DEAD-box helicase 24
Links

HGNC:13266

NCBI Gene ID: 57062

neXtProt AC: NX_Q9GZR7

UniProt: Q9GZR7
Chr Location

14q32.12; chr14:94048287-94081202 (-) GRCh38

MGI Vertebrate Homology

Ddx24 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX24
Gene Tree

Ddx24

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Targeted

2
Genomic Mutations

1 involving Ddx24
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout is embryonic lethal: embryos die between implantation and placentation. Heterozygous KO animals are viable and fertile.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

231

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx24

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All Sequences

76
RefSeq

8
UniProt

10
CCDS

CCDS26129.1, CCDS49152.1

Ensembl

ENSMUSG00000041645 (Evidence)
NCBI Gene

27225

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041645	Ensembl Gene Model \| MGI Sequence Detail	17849	C57BL/6J	± kb
transcript	ENSMUST00000110001	Ensembl \| MGI Sequence Detail	3063	Not Applicable
polypeptide	ENSMUSP00000105628	Ensembl \| MGI Sequence Detail	903	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006360 ATP-dependent RNA helicase DDX24

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR050079 DEAD box RNA helicase

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif
GlyGen

Q9ESV0 1 site, 1 O-linked glycan (1 site)

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All nucleic 233

cDNA 233

Microarray probesets 5

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MGI:1919702, MGI:1925876, MGI:2144875

Summaries

All 40

Gene Ontology 6

Phenotypes 12
Earliest

J:63823 Zhao Y, et al., Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32. Genomics. 2000 Aug 1;67(3):351-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ddx24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117478	Chr12:103392062-103392114 (-)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24