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Grm6 Gene Detail
Summary
  • Symbol
    Grm6
  • Name
    glutamate receptor, metabotropic 6
  • Synonyms
    mGluR6, nerg1, nob3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351343
    NCBI Gene: 108072
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:50741512-50757035 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 30.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    527 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351343
 protein coding gene Chr11:50741205-50757035 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018254
 protein coding gene Chr11:50043067-50059189 (+)
A/J MGP_AJ_G0018222
 protein coding gene Chr11:48134895-48150534 (+)
AKR/J MGP_AKRJ_G0018192
 protein coding gene Chr11:49660634-49675997 (+)
BALB/cJ MGP_BALBcJ_G0018192
 protein coding gene Chr11:48421375-48436924 (+)
C3H/HeJ MGP_C3HHeJ_G0018005
 protein coding gene Chr11:49648447-49665531 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018643
 protein coding gene Chr11:51515260-51532348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016296
 protein coding gene Chr11:45733924-45749845 (+)
CAST/EiJ MGP_CASTEiJ_G0017567
 protein coding gene Chr11:49660253-49676935 (+)
CBA/J MGP_CBAJ_G0017980
 protein coding gene Chr11:53904992-53922883 (+)
DBA/2J MGP_DBA2J_G0018087
 protein coding gene Chr11:47920536-47936731 (+)
FVB/NJ MGP_FVBNJ_G0018081
 protein coding gene Chr11:47557648-47573166 (+)
LP/J MGP_LPJ_G0018162
 protein coding gene Chr11:50415239-50433144 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018106
 protein coding gene Chr11:55401592-55418292 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018687
 protein coding gene Chr11:49752163-49769803 (+)
PWK/PhJ MGP_PWKPhJ_G0017345
 protein coding gene Chr11:48322656-48338894 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017140
 protein coding gene Chr11:49473146-49489789 (+)
WSB/EiJ MGP_WSBEiJ_G0017620
 protein coding gene Chr11:49395430-49413431 (+)



Homology
more
  • Human Ortholog
    GRM6, glutamate metabotropic receptor 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRM6, glutamate metabotropic receptor 6
  • Synonyms
    CSNB1B, GPRC1F, mGlu6, MGLUR6
  • Links
    NCBI Gene ID: 2916
    neXtProt AC: NX_O15303
    UniProt: O15303

  • Chr Location
    5q35.3; chr5:178977587-178996206 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Grm6 mouse models; 1 with human GRM6 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 8 alleles in 12 genetic backgrounds
    1 phenotype from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show loss of ON responses without significant alteration of OFF responses in visual transmission or changes in visual behavioral responses. ENU-induced mutant mice have an ERG that lacks the rod b-wave and scotopic threshold response, while the cone ERG is of large amplitude.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    8
  • cDNA Data
    14
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000617 Ensembl Gene Model | MGI Sequence Detail 15524 C57BL/6J ±  kb
    transcript ENSMUST00000000631 Ensembl | MGI Sequence Detail 4291 Not Applicable  
    polypeptide ENSMUSP00000000631 Ensembl | MGI Sequence Detail 871 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008268 metabotropic glutamate receptor 6
      (term hierarchy)
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000162 GPCR, family 3, metabotropic glutamate receptor
      IPR000112 GPCR, family 3, metabotropic glutamate receptor 6
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR050726 Metabotropic Glutamate Receptor
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q5NCH9 4 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 15
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10269, MGI:2684849, MGI:3605830, MGI:3605838, MGI:95830
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 12
      Phenotypes 58
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354914 Brockett AT, et al., Psilocybin decreases neural responsiveness and increases functional connectivity while preserving pure-tone frequency selectivity in mouse auditory cortex. J Neurophysiol. 2024 Jul 1;132(1):45-53
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory