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Plekhb1 Gene Detail
Summary
  • Symbol
    Plekhb1
  • Name
    pleckstrin homology domain containing, family B (evectins) member 1
  • Synonyms
    evt-1, PHR1, Phret1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351469
    NCBI Gene: 27276
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100292099-100311621 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.36 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    624 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351469
 protein coding gene Chr7:100291922-100311621 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032575
 protein coding gene Chr7:103541734-103563308 (-)
A/J MGP_AJ_G0032549
 protein coding gene Chr7:100928741-100947895 (-)
AKR/J MGP_AKRJ_G0032485
 protein coding gene Chr7:103330670-103349824 (-)
BALB/cJ MGP_BALBcJ_G0032560
 protein coding gene Chr7:100610554-100630014 (-)
C3H/HeJ MGP_C3HHeJ_G0032275
 protein coding gene Chr7:103711159-103731067 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033058
 protein coding gene Chr7:107466172-107484421 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030052
 protein coding gene Chr7:103326062-103344640 (-)
CAST/EiJ MGP_CASTEiJ_G0031602
 protein coding gene Chr7:95274831-95293982 (-)
CBA/J MGP_CBAJ_G0032242
 protein coding gene Chr7:111164977-111183120 (-)
DBA/2J MGP_DBA2J_G0032393
 protein coding gene Chr7:99263256-99281385 (-)
FVB/NJ MGP_FVBNJ_G0032350
 protein coding gene Chr7:99041415-99060807 (-)
LP/J MGP_LPJ_G0032483
 protein coding gene Chr7:104886525-104905849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032383
 protein coding gene Chr7:112575188-112593595 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033080
 protein coding gene Chr7:102596921-102615143 (-)
PWK/PhJ MGP_PWKPhJ_G0031320
 protein coding gene Chr7:92382286-92401376 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031163
 protein coding gene Chr7:89910645-89928824 (-)
WSB/EiJ MGP_WSBEiJ_G0031719
 protein coding gene Chr7:103301256-103320423 (-)



Homology
more
  • Human Ortholog
    PLEKHB1, pleckstrin homology domain containing B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHB1, pleckstrin homology domain containing B1
  • Synonyms
    KPL1, PHR1, PHRET1
  • Links
    NCBI Gene ID: 58473
    neXtProt AC: NX_Q9UF11
    UniProt: Q9UF11

  • Chr Location
    11q13.4; chr11:73646178-73662819 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Homozygous null mice are viable with no abnormalities detected in growth, behavior including balance, inner ear histology, or serum and urine electrolyte concentrations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    912
  • Tissues
    54
  • cDNA Data
    114
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030701 Ensembl Gene Model | MGI Sequence Detail 19523 C57BL/6J ±  kb
transcript ENSMUST00000079176 Ensembl | MGI Sequence Detail 2079 Not Applicable  
polypeptide ENSMUSP00000078175 Ensembl | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000031742 pleckstrin homology domain-containing family B member 1
    (term hierarchy)
  • PDB
    2D9V
  • InterPro Domains
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR039680 Pleckstrin homology domain-containing family B member 1/2
  • GlyGen
    Q9QYE9 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 115
    cDNA 114
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141901
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:296433 Marques RF, et al., Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models. Hum Mol Genet. 2020 Sep 29;29(16):2647-2661
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory