Golga5 MGI Mouse Gene Detail - MGI:1351475

Symbol

Golga5
Name

golgin A5
Synonyms

Ret-II

Feature Type

protein coding gene
IDs

MGI:1351475
NCBI Gene: 27277
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:102435394-102464166 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 51.51 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

908 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351475	protein coding gene	Chr12:102435372-102464274 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020032	protein coding gene	Chr12:104096988-104125882 (+)
A/J	MGP_AJ_G0019988	protein coding gene	Chr12:100103337-100133175 (+)
AKR/J	MGP_AKRJ_G0019964	protein coding gene	Chr12:102943484-102972096 (+)
BALB/cJ	MGP_BALBcJ_G0019974	protein coding gene	Chr12:100433229-100462610 (+)
C3H/HeJ	MGP_C3HHeJ_G0019776	protein coding gene	Chr12:103405610-103436795 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020423	protein coding gene	Chr12:107353122-107381796 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018036	protein coding gene	Chr12:97123558-97152552 (+)
CAST/EiJ	MGP_CASTEiJ_G0019322	protein coding gene	Chr12:98237146-98267157 (+)
CBA/J	MGP_CBAJ_G0019748	protein coding gene	Chr12:111323206-111352812 (+)
DBA/2J	MGP_DBA2J_G0019859	protein coding gene	Chr12:99622024-99650876 (+)
FVB/NJ	MGP_FVBNJ_G0019848	protein coding gene	Chr12:98350649-98379246 (+)
LP/J	MGP_LPJ_G0019935	protein coding gene	Chr12:103951998-103976865 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019888	protein coding gene	Chr12:114802648-114832855 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020452	protein coding gene	Chr12:102445920-102474622 (+)
PWK/PhJ	MGP_PWKPhJ_G0019085	protein coding gene	Chr12:94178630-94209419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018881	protein coding gene	Chr12:96629354-96659135 (+)
WSB/EiJ	MGP_WSBEiJ_G0019376	protein coding gene	Chr12:103338947-103368327 (+)

Human Ortholog

GOLGA5, golgin A5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GOLGA5, golgin A5
Synonyms

GOLIM5, ret-II, RFG5
Links

HGNC:4428

NCBI Gene ID: 9950

neXtProt AC: NX_Q8TBA6

UniProt: Q8TBA6
Chr Location

14q32.12; chr14:92794305-92839947 (+) GRCh38

MGI Vertebrate Homology

Golga5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GOLGA5
Gene Tree

Golga5

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Phenotype Summary

14 phenotypes from 4 alleles in 4 genetic backgrounds
7 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

6
Targeted

3
Genomic Mutations

1 involving Golga5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout does not result in an obvious phenotype and does not affect Golgi apparatus morphology.

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All GO Annotations

30
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

26
cDNA Data

57
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase golga5

ZFIN golga5

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All Sequences

45
RefSeq

6
UniProt

2
CCDS

CCDS36526.1

Ensembl

ENSMUSG00000021192 (Evidence)
NCBI Gene

27277

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021192	Ensembl Gene Model \| MGI Sequence Detail	28773	C57BL/6J	± kb
transcript	ENSMUST00000179218	Ensembl \| MGI Sequence Detail	2827	Not Applicable
polypeptide	ENSMUSP00000137305	Ensembl \| MGI Sequence Detail	729	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008134 golgin subfamily A member 5

(term hierarchy)
InterPro Domains

IPR019177 Golgin subfamily A member 5
GlyGen

Q9QYE6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 58

cDNA 57

Other 1

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 12
Earliest

J:52425 Bascom RA, et al., Identification and characterization of golgin-84, a novel Golgi integral membrane protein a cyto-plasmic coiled-coil domain [published erratum appears in J Biol Chem 1999 Apr 30;274(18):12950]. J Biol Chem. 1999 Jan 29;274(5):2953-62
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Golga5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114761	Chr12:102435382-102435415 (+)	5 bp
Tssr114762	Chr12:102435425-102435440 (+)	39 bp
Tssr114763	Chr12:102435486-102435577 (+)	138 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24