Tnfrsf12a MGI Mouse Gene Detail - MGI:1351484 - tumor necrosis factor receptor superfamily, member 12a

Symbol

Tnfrsf12a
Name

tumor necrosis factor receptor superfamily, member 12a
Synonyms

Fn14, TweakR, TWEAK-R

Feature Type

protein coding gene
IDs

MGI:1351484
NCBI Gene: 27279
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:23894419-23896423 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 11.99 cM
Mapping Data

3 experiments

SNPs within 2kb

82 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351484	protein coding gene	Chr17:23894419-23896442 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023263	protein coding gene	Chr17:22590822-22592822 (-)
A/J	MGP_AJ_G0023223	protein coding gene	Chr17:21941077-21943077 (-)
AKR/J	MGP_AKRJ_G0023193	protein coding gene	Chr17:22017415-22019417 (-)
BALB/cJ	MGP_BALBcJ_G0023228	protein coding gene	Chr17:22155509-22157510 (-)
C3H/HeJ	MGP_C3HHeJ_G0022988	protein coding gene	Chr17:22378919-22380920 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023671	protein coding gene	Chr17:23572320-23574322 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021152	protein coding gene	Chr17:19510113-19512118 (-)
CAST/EiJ	MGP_CASTEiJ_G0022494	protein coding gene	Chr17:22211770-22213769 (-)
CBA/J	MGP_CBAJ_G0022964	protein coding gene	Chr17:24382696-24384697 (-)
DBA/2J	MGP_DBA2J_G0023096	protein coding gene	Chr17:21569375-21571375 (-)
FVB/NJ	MGP_FVBNJ_G0023063	protein coding gene	Chr17:21294027-21296029 (-)
LP/J	MGP_LPJ_G0023170	protein coding gene	Chr17:22848900-22850900 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023082	protein coding gene	Chr17:24145202-24147207 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023710	protein coding gene	Chr17:22310695-22312695 (-)
PWK/PhJ	MGP_PWKPhJ_G0022242	protein coding gene	Chr17:20354429-20356428 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022062	protein coding gene	Chr17:20334557-20336569 (-)
WSB/EiJ	MGP_WSBEiJ_G0022557	protein coding gene	Chr17:22365883-22367884 (-)

Human Ortholog

TNFRSF12A, TNF receptor superfamily member 12A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFRSF12A, TNF receptor superfamily member 12A
Synonyms

CD266, FN14, TWEAKR
Links

HGNC:18152

NCBI Gene ID: 51330

neXtProt AC: NX_Q9NP84

UniProt: Q9NP84
Chr Location

16p13.3; chr16:3018445-3022383 (+) GRCh38

MGI Vertebrate Homology

Tnfrsf12a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TNFRSF12A
Gene Tree

Tnfrsf12a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

5
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

10 strains or lines available

Mice homozygous for a knock-out allele exhibit significantly reduced liver progenitor ("oval") cell proliferation in response to chemically-induced liver injury.

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

53
cDNA Data

15
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnfrsf12a

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All Sequences

50
RefSeq

4
UniProt

4
CCDS

CCDS28456.1, CCDS50011.1

Ensembl

ENSMUSG00000023905 (Evidence)
NCBI Gene

27279

			Length	Strain/Species	Flank
genomic	27279	NCBI Gene Model \| MGI Sequence Detail	2005	C57BL/6J	± kb
transcript	NM_013749	RefSeq \| MGI Sequence Detail	980	C57BL/6
polypeptide	Q9CR75	UniProt \| EBI \| MGI Sequence Detail	129	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001955 tumor necrosis factor receptor superfamily member 12A

(term hierarchy)
InterPro Domains

IPR022316 Tumour necrosis factor receptor 12

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All nucleic 16

cDNA 15

Other 1

Microarray probesets 4

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MGI:2146391, MGI:2147148

Summaries

All 86

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 36
Earliest

J:58335 Meighan-Mantha RL, et al., The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem. 1999 Nov 12;274(46):33166-76
Latest

J:357638 Hazell G, et al., Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1(G93A) amyotrophic lateral sclerosis (ALS) mouse model. Skelet Muscle. 2024 Oct 14;14(1):23

TSS for Tnfrsf12a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146644	Chr17:23896451-23896458 (-)	-32 bp
Tssr146643	Chr17:23896406-23896430 (-)	5 bp
Tssr146642	Chr17:23895634-23895658 (-)	777 bp
Tssr146641	Chr17:23895615-23895620 (-)	805 bp
Tssr146640	Chr17:23895561-23895603 (-)	841 bp
Tssr146639	Chr17:23895536-23895557 (-)	876 bp
Tssr146638	Chr17:23894825-23894862 (-)	1,579 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24