Smok1 Gene Detail

Summary

• Symbol
  Smok1
• Name
  sperm motility kinase 1
• Synonyms
  Smok, Tcr-1, Tcr1

• Feature Type
  protein coding gene
• IDs
  MGI:1351488
  NCBI Gene: 27262
• Alliance
  gene page
• Candidate for QTL
  1 QTL

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, Syntenic
• Mapping Data
  5 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  1
• Transgenic
  1
• Find Mice (IMSR)
  0 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  27
• GO References
  6

Sequences &
Gene Models

• All Sequences
  2
• UniProt
  1

• NCBI Gene
  27262

Representative Sequences			Length	Strain/Species
genomic	AJ245455	GenBank | ENA | DDBJ | MGI Sequence Detail	1590	STOCK t
polypeptide	Q9QYZ4	UniProt | EBI | MGI Sequence Detail	484	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000015970 sperm motility kinase 1
  (term hierarchy)

Molecular
Reagents

• All nucleic 2

  Genomic 2

Other
Accession IDs

MGD-MRK-14843, MGD-MRK-14844, MGI:98552

References

• Summaries
  All 27

  Gene Ontology 6

  Phenotypes 2
• Earliest
  J:6915 Klein J, et al., H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17. Immunogenetics. 1982;16(4):285-317
• Latest
  J:183481 Bauer H, et al., The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance. PLoS Genet. 2012 Mar;8(3):e1002567

Smok1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Nidd2n	Chr14, 31.49 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 14, Smok1 (7.7 cM, formerly Tcr1) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Nidd2n (22.5 cM) maps near candidate gene Smok1.

*cM position of peak correlated region/marker