Insl6 MGI Mouse Gene Detail - MGI:1351595

Symbol

Insl6
Name

insulin-like 6
Synonyms

relaxin/insulin-like factor 1, RIF1

Feature Type

protein coding gene
IDs

MGI:1351595
NCBI Gene: 27356
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:29298754-29302718 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 23.82 cM, cytoband C3
Mapping Data

4 experiments

SNPs within 2kb

187 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351595	protein coding gene	Chr19:29298744-29302756 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025019	protein coding gene	Chr19:27769391-27775442 (-)
A/J	MGP_AJ_G0024996	protein coding gene	Chr19:26372887-26377532 (-)
AKR/J	MGP_AKRJ_G0024964	protein coding gene	Chr19:27325923-27333247 (-)
BALB/cJ	MGP_BALBcJ_G0024995	protein coding gene	Chr19:26421584-26425592 (-)
C3H/HeJ	MGP_C3HHeJ_G0024751	protein coding gene	Chr19:27303690-27309863 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025436	protein coding gene	Chr19:28541776-28547326 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022855	protein coding gene	Chr19:26347581-26351583 (-)
CAST/EiJ	MGP_CASTEiJ_G0024221	protein coding gene	Chr19:27130579-27135973 (-)
CBA/J	MGP_CBAJ_G0024729	protein coding gene	Chr19:29887660-29894129 (-)
DBA/2J	MGP_DBA2J_G0024861	protein coding gene	Chr19:26331454-26335554 (-)
FVB/NJ	MGP_FVBNJ_G0024823	protein coding gene	Chr19:26187557-26192237 (-)
LP/J	MGP_LPJ_G0024946	protein coding gene	Chr19:27768666-27779540 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024850	protein coding gene	Chr19:29836696-29840671 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025491	protein coding gene	Chr19:27347721-27352847 (-)
PWK/PhJ	MGP_PWKPhJ_G0023969	protein coding gene	Chr19:26004557-26008912 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023773	protein coding gene	Chr19:26622898-26626922 (-)
WSB/EiJ	MGP_WSBEiJ_G0024288	protein coding gene	Chr19:27396101-27401013 (-)

Human Ortholog

INSL6, insulin like 6

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INSL6, insulin like 6
Synonyms

RIF1
Links

HGNC:6089

NCBI Gene ID: 11172

neXtProt AC: NX_Q9Y581

UniProt: Q9Y581
Chr Location

9p24.1; chr9:4991976-5185647 (-) GRCh38

MGI Vertebrate Homology

Insl6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: INSL6
Protein SuperFamily

Insulin-like_peptide_6
Gene Tree

Insl6

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Phenotype Summary

11 phenotypes from 1 allele in 2 genetic backgrounds
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with male germ cell apoptosis and reduced sperm motility.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

23
cDNA Data

26
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS29732.1

Ensembl

ENSMUSG00000050957 (Evidence)
NCBI Gene

27356

			Length	Strain/Species	Flank
genomic	27356	NCBI Gene Model \| MGI Sequence Detail	3965	C57BL/6J	± kb
transcript	NM_013754	RefSeq \| MGI Sequence Detail	660	FVB/N
polypeptide	Q9QY05	UniProt \| EBI \| MGI Sequence Detail	191	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009061 insulin-like peptide INSL6

(term hierarchy)
InterPro Domains

IPR022353 Insulin, conserved site

IPR016179 Insulin-like

IPR017100 Insulin-like peptide 6

IPR036438 Insulin-like superfamily

IPR051042 Mammalian Reproductive Hormone Insulin-like

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All nucleic 30

Genomic 1

cDNA 26

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 5
Earliest

J:58920 Hsu SY, Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. Mol Endocrinol. 1999 Dec;13(12):2163-74
Latest

J:325297 Maruyama S, et al., Relaxin Family Member Insulin-Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models. J Am Heart Assoc. 2018 Jun 10;7(12)

TSS for Insl6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158751	Chr19:29302713-29302771 (-)	-24 bp
Tssr158750	Chr19:29302510-29302521 (-)	202 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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