Sh2d2a MGI Mouse Gene Detail - MGI:1351596

Symbol

Sh2d2a
Name

SH2 domain containing 2A
Synonyms

Lad, Lck-associated adapter protein, RIBP, Rlk/Itk-binding protein, TSAd

Feature Type

protein coding gene
IDs

MGI:1351596
NCBI Gene: 27371
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:87754062-87763029 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.78 cM
Mapping Data

7 experiments

SNPs within 2kb

235 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351596	protein coding gene	Chr3:87754062-87763116 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027370	protein coding gene	Chr3:87973472-87982429 (+)
A/J	MGP_AJ_G0027334	protein coding gene	Chr3:84986844-84995842 (+)
AKR/J	MGP_AKRJ_G0027300	protein coding gene	Chr3:87067739-87076709 (+)
BALB/cJ	MGP_BALBcJ_G0027343	protein coding gene	Chr3:85084235-85093205 (+)
C3H/HeJ	MGP_C3HHeJ_G0027086	protein coding gene	Chr3:87339734-87348696 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027789	protein coding gene	Chr3:91207416-91216371 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025142	protein coding gene	Chr3:80609936-80619011 (+)
CAST/EiJ	MGP_CASTEiJ_G0026533	protein coding gene	Chr3:87555846-87564806 (+)
CBA/J	MGP_CBAJ_G0027061	protein coding gene	Chr3:94288157-94297155 (+)
DBA/2J	MGP_DBA2J_G0027197	protein coding gene	Chr3:84480455-84489425 (+)
FVB/NJ	MGP_FVBNJ_G0027166	protein coding gene	Chr3:82750943-82760836 (+)
LP/J	MGP_LPJ_G0027305	protein coding gene	Chr3:88934324-88943273 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027185	protein coding gene	Chr3:100551823-100560839 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027847	protein coding gene	Chr3:86823863-86832906 (+)
PWK/PhJ	MGP_PWKPhJ_G0026266	protein coding gene	Chr3:84275124-84284071 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026083	protein coding gene	Chr3:86013844-86022682 (+)
WSB/EiJ	MGP_WSBEiJ_G0026612	protein coding gene	Chr3:87184586-87193543 (+)

Human Ortholog

SH2D2A, SH2 domain containing 2A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH2D2A, SH2 domain containing 2A
Synonyms

F2771, SCAP, TSAD, VRAP
Links

HGNC:10821

NCBI Gene ID: 9047

neXtProt AC: NX_Q9NP31

UniProt: Q9NP31
Chr Location

1q23.1; chr1:156806243-156816848 (-) GRCh38

MGI Vertebrate Homology

Sh2d2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SH2D2A
Gene Tree

Sh2d2a

Diseases

2 with human SH2D2A associations

				Human Disease	Mouse Models
				juvenile rheumatoid arthritis IDs juvenile rheumatoid arthritis DOID:676 DOID:10129 DOID:1264 DOID:675 ICD10CM:M08.4 ICD9CM:714.3 ICD9CM:714.31 ICD9CM:714.32 ICD9CM:714.33 NCI:C26979 NCI:C61279 OMIM:604302 ORDO:92 UMLS_CUI:C0157916 UMLS_CUI:C0157917 UMLS_CUI:C0157918 UMLS_CUI:C0409667
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Sh2d2a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available

While T cell development is normal, T cell proliferation in response to TCR-mediated activation is impaired in homozygous null mice.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sh2d2a

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All Sequences

48
RefSeq

12
UniProt

3
CCDS

CCDS17455.1, CCDS38476.1

Ensembl

ENSMUSG00000028071 (Evidence)
NCBI Gene

27371

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028071	Ensembl Gene Model \| MGI Sequence Detail	8968	C57BL/6J	± kb
transcript	ENSMUST00000107581	Ensembl \| MGI Sequence Detail	1807	Not Applicable
polypeptide	ENSMUSP00000103207	Ensembl \| MGI Sequence Detail	374	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014814 SH2 domain-containing protein 2A

(term hierarchy)
InterPro Domains

IPR035884 SH2D2A, SH2 domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

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All nucleic 16

Genomic 1

cDNA 14

Other 1

Microarray probesets 3

Summaries

All 47

Diseases 1

Gene Ontology 5

Phenotypes 21
Earliest

J:58458 Choi YB, et al., Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. J Immunol. 1999 Nov 15;163(10):5242-9
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Sh2d2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29832	Chr3:87752602-87752606 (+)	-1,458 bp
Tssr29833	Chr3:87754032-87754079 (+)	-6 bp
Tssr29834	Chr3:87754085-87754095 (+)	28 bp
Tssr29835	Chr3:87754147-87754161 (+)	92 bp
Tssr29836	Chr3:87754188-87754200 (+)	132 bp
Tssr29837	Chr3:87754295-87754306 (+)	239 bp
Tssr29838	Chr3:87754311-87754374 (+)	281 bp
Tssr29839	Chr3:87754443-87754454 (+)	387 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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