Dusp13b MGI Mouse Gene Detail - MGI:1351599 - dual specificity phosphatase 13B

Symbol

Dusp13b
Name

dual specificity phosphatase 13B
Synonyms

Dusp13, LMW-DSP6, LOC382853, TMDP, TS-DSP6

Feature Type

protein coding gene
IDs

MGI:1351599
NCBI Gene: 27389
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:21783463-21792947 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 11.85 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

315 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351599	protein coding gene	Chr14:21783462-21792947 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021054	protein coding gene	Chr14:14574783-14593264 (-)
A/J	MGP_AJ_G0021003	protein coding gene	Chr14:14191767-14209554 (-)
AKR/J	MGP_AKRJ_G0020980	protein coding gene	Chr14:14756591-14774436 (-)
BALB/cJ	MGP_BALBcJ_G0021006	protein coding gene	Chr14:14298755-14316518 (-)
C3H/HeJ	MGP_C3HHeJ_G0020790	protein coding gene	Chr14:14681274-14699485 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021439	protein coding gene	Chr14:15056672-15074459 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019007	protein coding gene	Chr14:14506048-14524602 (-)
CAST/EiJ	MGP_CASTEiJ_G0020314	protein coding gene	Chr14:14486646-14508117 (-)
CBA/J	MGP_CBAJ_G0020756	protein coding gene	Chr14:15825432-15848675 (-)
DBA/2J	MGP_DBA2J_G0020879	protein coding gene	Chr14:14027383-14045107 (-)
FVB/NJ	MGP_FVBNJ_G0020862	protein coding gene	Chr14:13914119-13932397 (-)
LP/J	MGP_LPJ_G0020955	protein coding gene	Chr14:14782093-14801564 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020888	protein coding gene	Chr14:15581150-15602100 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021472	protein coding gene	Chr14:14535208-14554286 (-)
PWK/PhJ	MGP_PWKPhJ_G0020063	protein coding gene	Chr14:13613843-13632513 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019885	protein coding gene	Chr14:14353537-14371554 (-)
WSB/EiJ	MGP_WSBEiJ_G0020370	protein coding gene	Chr14:14529451-14547271 (-)

Human Ortholog

DUSP13B, dual specificity phosphatase 13B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP13B, dual specificity phosphatase 13B
Synonyms

DUSP13, MDSP, SKRP4, TMDP
Links

HGNC:19681

NCBI Gene ID: 51207

neXtProt AC: NX_Q6B8I1, NX_Q9UII6

UniProt: Q9UII6
Chr Location

10q22.2; chr10:75094432-75109206 (-) GRCh38

MGI Vertebrate Homology

Dusp13b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP13B
Gene Tree

Dusp13b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

4
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp13b

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All Sequences

53
RefSeq

10
UniProt

5
CCDS

CCDS26864.1, CCDS88592.1, CCDS88593.1

Ensembl

ENSMUSG00000021768 (Evidence)
NCBI Gene

27389

			Length	Strain/Species	Flank
genomic	27389	NCBI Gene Model \| MGI Sequence Detail	9485	C57BL/6J	± kb
transcript	NM_001374075	RefSeq \| MGI Sequence Detail	1321	C57BL/6
polypeptide	Q9QYJ7	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006740 dual specificity protein phosphatase 13B

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR020405 Atypical dual specificity phosphatase, subfamily A

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR016130 Protein-tyrosine phosphatase, active site

IPR029021 Protein-tyrosine phosphatase-like

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 7

cDNA 7

Microarray probesets 4

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MGI:2686049, MGI:7470868

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 8
Earliest

J:59256 Nakamura K, et al., Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Biochem J. 1999 Dec 15;344 Pt 3:819-25
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dusp13b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127686	Chr14:21792977-21792986 (-)	-35 bp
Tssr127685	Chr14:21792972-21792976 (-)	-27 bp
Tssr127684	Chr14:21792938-21792961 (-)	-3 bp
Tssr127683	Chr14:21791548-21791571 (-)	1,387 bp
Tssr127682	Chr14:21791531-21791538 (-)	1,412 bp
Tssr127681	Chr14:21791517-21791524 (-)	1,426 bp
Tssr127680	Chr14:21790490-21790513 (-)	2,445 bp
Tssr127679	Chr14:21790463-21790488 (-)	2,471 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24