Sytl4 MGI Mouse Gene Detail - MGI:1351606

Symbol

Sytl4
Name

synaptotagmin-like 4
Synonyms

granuphilin-a, granuphilin-b, Slp4

Feature Type

protein coding gene
IDs

MGI:1351606
NCBI Gene: 27359
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

ChrX:132837134-132882561 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 55.47 cM, cytoband E3
Mapping Data

3 experiments

SNPs within 2kb

849 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351606	protein coding gene	ChrX:132837134-132882569 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036059	protein coding gene	ChrX:131079241-131124668 (-)
A/J	MGP_AJ_G0036041	protein coding gene	ChrX:130509616-130553531 (-)
AKR/J	MGP_AKRJ_G0035960	protein coding gene	ChrX:134678851-134724197 (-)
BALB/cJ	MGP_BALBcJ_G0036032	protein coding gene	ChrX:128956853-129002977 (-)
C3H/HeJ	MGP_C3HHeJ_G0035736	protein coding gene	ChrX:131163960-131207952 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036554	protein coding gene	ChrX:134946628-134990839 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033382	protein coding gene	ChrX:122714253-122760895 (-)
CAST/EiJ	MGP_CASTEiJ_G0035023	protein coding gene	ChrX:112040826-112087529 (-)
CBA/J	MGP_CBAJ_G0035713	protein coding gene	ChrX:138984383-139028310 (-)
DBA/2J	MGP_DBA2J_G0035866	protein coding gene	ChrX:129851330-129895218 (-)
FVB/NJ	MGP_FVBNJ_G0035808	protein coding gene	ChrX:129160125-129207464 (-)
LP/J	MGP_LPJ_G0035959	protein coding gene	ChrX:131960494-132005589 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035836	protein coding gene	ChrX:146380200-146432285 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036583	protein coding gene	ChrX:130512772-130561824 (-)
PWK/PhJ	MGP_PWKPhJ_G0034715	protein coding gene	ChrX:108998409-109043596 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034547	protein coding gene	ChrX:112666808-112713560 (-)
WSB/EiJ	MGP_WSBEiJ_G0035160	protein coding gene	ChrX:128893591-128940232 (-)

Human Ortholog

SYTL4, synaptotagmin like 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYTL4, synaptotagmin like 4
Synonyms

SLP4
Links

HGNC:15588

NCBI Gene ID: 94121

neXtProt AC: NX_Q96C24

UniProt: Q96C24
Chr Location

Xq22.1; chrX:100671783-100732123 (-) GRCh38

MGI Vertebrate Homology

Sytl4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYTL4
Gene Tree

Sytl4

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted inactivation of this gene leads to reduced body weight, enhanced glucose tolerance, defective granule docking at the plasma membrane in pancreatic beta cells and corticotrophs, and a significant increase in evoked insulin and adrenocorticotropinsecretion.

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All GO Annotations

37
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

13
cDNA Data

18
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sytl4

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All Sequences

52
RefSeq

10
UniProt

3
CCDS

CCDS30388.1, CCDS72429.1, CCDS81169.1

Ensembl

ENSMUSG00000031255 (Evidence)
NCBI Gene

27359

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031255	Ensembl Gene Model \| MGI Sequence Detail	45428	C57BL/6J	± kb
transcript	ENSMUST00000033608	Ensembl \| MGI Sequence Detail	3753	Not Applicable
polypeptide	ENSMUSP00000033608	Ensembl \| MGI Sequence Detail	673	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015915 synaptotagmin-like protein 4

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR041282 FYVE-type zinc finger

IPR010911 Rab-binding domain

IPR043567 Synaptotagmin-like 1-5, C2B domain

IPR037303 Synaptotagmin-like protein 4/5, C2A domain

IPR044134 Synaptotagmin-like protein 4 , FYVE-related domain

IPR011011 Zinc finger, FYVE/PHD-type

IPR013083 Zinc finger, RING/FYVE/PHD-type
GlyGen

Q9R0Q1 1 site, 1 N-linked glycan (1 site)

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 5

Summaries

All 50

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 12
Earliest

J:30814 Neophytou PI, et al., A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells. Diabetes. 1996 Feb;45(2):127-33
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sytl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164130	ChrX:132882514-132882561 (-)	23 bp
Tssr164129	ChrX:132882471-132882503 (-)	74 bp
Tssr164128	ChrX:132882456-132882468 (-)	99 bp
Tssr164127	ChrX:132862582-132862603 (-)	19,968 bp
Tssr164126	ChrX:132862521-132862524 (-)	20,038 bp
Tssr164125	ChrX:132862509-132862510 (-)	20,051 bp
Tssr164124	ChrX:132862496-132862503 (-)	20,061 bp
Tssr164123	ChrX:132862470-132862479 (-)	20,086 bp
Tssr164122	ChrX:132862423-132862426 (-)	20,136 bp
Tssr164121	ChrX:132862376-132862398 (-)	20,174 bp
Tssr164120	ChrX:132861475-132861504 (-)	21,071 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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