Exoc6 MGI Mouse Gene Detail - MGI:1351611 - exocyst complex component 6

Symbol

Exoc6
Name

exocyst complex component 6
Synonyms

4833405E05Rik, hbd, msec15, Sec15, Sec15l1

Feature Type

protein coding gene
IDs

MGI:1351611
NCBI Gene: 107371
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr19:37525181-37672499 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 32.32 cM
Mapping Data

7 experiments

SNPs within 2kb

4296 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351611	protein coding gene	Chr19:37509327-37672507 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025082	protein coding gene	Chr19:36538976-36678112 (+)
A/J	MGP_AJ_G0025058	protein coding gene	Chr19:34769755-34901617 (+)
AKR/J	MGP_AKRJ_G0025026	protein coding gene	Chr19:35964271-36095411 (+)
BALB/cJ	MGP_BALBcJ_G0025056	protein coding gene	Chr19:34858547-34989389 (+)
C3H/HeJ	MGP_C3HHeJ_G0024815	protein coding gene	Chr19:36017514-36158117 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025497	protein coding gene	Chr19:37609626-37746089 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022916	protein coding gene	Chr19:34135440-34263123 (+)
CAST/EiJ	MGP_CASTEiJ_G0024282	protein coding gene	Chr19:35866369-36011645 (+)
CBA/J	MGP_CBAJ_G0024792	protein coding gene	Chr19:39342480-39491330 (+)
DBA/2J	MGP_DBA2J_G0024924	protein coding gene	Chr19:34623023-34755461 (+)
FVB/NJ	MGP_FVBNJ_G0024885	protein coding gene	Chr19:34432521-34563178 (+)
LP/J	MGP_LPJ_G0025010	protein coding gene	Chr19:36636849-36779436 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024916	protein coding gene	Chr19:39155994-39299965 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025555	protein coding gene	Chr19:36041605-36177211 (+)
PWK/PhJ	MGP_PWKPhJ_G0024034	protein coding gene	Chr19:34476099-34608286 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023834	protein coding gene	Chr19:34885663-35025111 (+)
WSB/EiJ	MGP_WSBEiJ_G0024349	protein coding gene	Chr19:36133009-36265140 (+)

Human Ortholog

EXOC6, exocyst complex component 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EXOC6, exocyst complex component 6
Synonyms

EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p
Links

HGNC:23196

NCBI Gene ID: 54536

neXtProt AC: NX_Q8TAG9

UniProt: Q8TAG9
Chr Location

10q23.33; chr10:92826831-93059493 (+) GRCh38

MGI Vertebrate Homology

Exoc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EXOC6
Protein SuperFamily

Sec15
Gene Tree

Exoc6

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Phenotype Summary

31 phenotypes from 2 alleles in 4 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

2
Gene trapped

12
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a spontaneous mutation exhibit severe microcytic anemia, erythrocyte hyperchromia, and markedly increased levels of red cell protoporphyrin.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

19
cDNA Data

49
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase exoc6

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All Sequences

49
RefSeq

4
UniProt

6
CCDS

CCDS29779.1

Ensembl

ENSMUSG00000053799 (Evidence)
NCBI Gene

107371

			Length	Strain/Species	Flank
genomic	107371	NCBI Gene Model \| MGI Sequence Detail	147319	C57BL/6J	± kb
transcript	NM_175353	RefSeq \| MGI Sequence Detail	2737	ZRU/MplStud
polypeptide	Q8R313	UniProt \| EBI \| MGI Sequence Detail	802	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007253 exocyst complex component 6

(term hierarchy)
InterPro Domains

IPR042044 EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2

IPR007225 Exocyst complex component EXOC6/Sec15

IPR042045 Exocyst complex component EXOC6/Sec15, C-terminal, domain 1

IPR048359 Exocyst complex component EXOC6/Sec15, N-terminal domain

IPR046361 Exocyst complex subunit EXOC6/Sec15, C-terminal

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All nucleic 51

Genomic 2

cDNA 49

Microarray probesets 6

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MGD-MRK-10640, MGI:2147727, MGI:96028

Summaries

All 53

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 22
Earliest

J:5208 Scheufler H, [An additional house mouse mutant with anemia (hemoglobin deficiency)]. Z Versuchstierkd. 1969;11(5):348-53
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Exoc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156225	Chr19:37525057-37525083 (+)	-111 bp
Tssr156226	Chr19:37525084-37525105 (+)	-86 bp
Tssr156227	Chr19:37525245-37525270 (+)	77 bp
Tssr156228	Chr19:37525443-37525446 (+)	264 bp
Tssr156229	Chr19:37535821-37535842 (+)	10,651 bp
Tssr156230	Chr19:37538845-37538916 (+)	13,700 bp
Tssr156231	Chr19:37545166-37545167 (+)	19,986 bp
Tssr156232	Chr19:37565418-37565450 (+)	40,253 bp
Tssr156233	Chr19:37590985-37590989 (+)	65,806 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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