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Mrpl39 Gene Detail
Summary
  • Symbol
    Mrpl39
  • Name
    mitochondrial ribosomal protein L39
  • Synonyms
    MRP-L5, Rpml5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351620
    NCBI Gene: 27393
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:84515068-84532261 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 46.92 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    618 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351620
 protein coding gene Chr16:84514464-84532630 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022967
 protein coding gene Chr16:85293663-85312716 (-)
A/J MGP_AJ_G0022935
 protein coding gene Chr16:81408372-81426205 (-)
AKR/J MGP_AKRJ_G0022905
 protein coding gene Chr16:83799939-83822126 (-)
BALB/cJ MGP_BALBcJ_G0022937
 protein coding gene Chr16:81863947-81882956 (-)
C3H/HeJ MGP_C3HHeJ_G0022699
 protein coding gene Chr16:84375732-84397260 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023384
 protein coding gene Chr16:88058672-88082308 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020888
 protein coding gene Chr16:79353155-79370424 (-)
CAST/EiJ MGP_CASTEiJ_G0022221
 protein coding gene Chr16:84823319-84844338 (-)
CBA/J MGP_CBAJ_G0022668
 protein coding gene Chr16:91815482-91835074 (-)
DBA/2J MGP_DBA2J_G0022802
 protein coding gene Chr16:81286017-81304364 (-)
FVB/NJ MGP_FVBNJ_G0022777
 protein coding gene Chr16:80484683-80503081 (-)
LP/J MGP_LPJ_G0022871
 protein coding gene Chr16:84977865-85000852 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022796
 protein coding gene Chr16:96264602-96285936 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023402
 protein coding gene Chr16:84271947-84293580 (-)
PWK/PhJ MGP_PWKPhJ_G0021963
 protein coding gene Chr16:81444362-81462068 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021793
 protein coding gene Chr16:83777566-83795915 (-)
WSB/EiJ MGP_WSBEiJ_G0022269
 protein coding gene Chr16:84526587-84550139 (-)



Homology
more
  • Human Ortholog
    MRPL39, mitochondrial ribosomal protein L39
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPL39, mitochondrial ribosomal protein L39
  • Synonyms
    C21orf92, COXPD59, L39mt, L5mt, mL39, MRP-L5, MRPL5, MSTP003, PRED22, PRED66, RPML5
  • Links
    NCBI Gene ID: 54148
    neXtProt AC: NX_Q9NYK5
    UniProt: Q9NYK5

  • Chr Location
    21q21.3; chr21:25585656-25607859 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MRPL39 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    360 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    69
  • cDNA Data
    73
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27393 NCBI Gene Model | MGI Sequence Detail 17194 C57BL/6J ±  kb
    transcript NM_001384095 RefSeq | MGI Sequence Detail 2627 C57BL/6  
    polypeptide Q9JKF7 UniProt | EBI | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 73
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1889207
    References
    more
    • Summaries
      All 392
      Developmental Gene Expression 3
      Diseases 7
      Gene Ontology 9
      Phenotypes 360
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory