Fam50a MGI Mouse Gene Detail - MGI:1351626 - family with sequence similarity 50, member A

Symbol

Fam50a
Name

family with sequence similarity 50, member A
Synonyms

D0HXS9928E, XAP-5

Feature Type

protein coding gene
IDs

MGI:1351626
NCBI Gene: 108160
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

ChrX:73356639-73363755 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.98 cM
Mapping Data

1 experiment

SNPs within 2kb

184 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351626	protein coding gene	ChrX:73356589-73363761 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035841	protein coding gene	ChrX:70112497-70119706 (+)
A/J	MGP_AJ_G0035822	protein coding gene	ChrX:70297514-70304365 (+)
AKR/J	MGP_AKRJ_G0035747	protein coding gene	ChrX:72199147-72206189 (+)
BALB/cJ	MGP_BALBcJ_G0035807	protein coding gene	ChrX:69324085-69331390 (+)
C3H/HeJ	MGP_C3HHeJ_G0035512	protein coding gene	ChrX:70587326-70595286 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036337	protein coding gene	ChrX:72274977-72282819 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033181	protein coding gene	ChrX:69363583-69370287 (+)
CAST/EiJ	MGP_CASTEiJ_G0034803	protein coding gene	ChrX:55970040-55976926 (+)
CBA/J	MGP_CBAJ_G0035487	protein coding gene	ChrX:74273517-74280376 (+)
DBA/2J	MGP_DBA2J_G0035644	protein coding gene	ChrX:69757344-69764237 (+)
FVB/NJ	MGP_FVBNJ_G0035588	protein coding gene	ChrX:69101479-69108359 (+)
LP/J	MGP_LPJ_G0035729	protein coding gene	ChrX:70891809-70898912 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035626	protein coding gene	ChrX:76834991-76841909 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036359	protein coding gene	ChrX:69930087-69937912 (+)
PWK/PhJ	MGP_PWKPhJ_G0034502	protein coding gene	ChrX:53929366-53936290 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034336	protein coding gene	ChrX:56836627-56843498 (+)
WSB/EiJ	MGP_WSBEiJ_G0034944	protein coding gene	ChrX:69214733-69221776 (+)

Human Ortholog

FAM50A, family with sequence similarity 50 member A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM50A, family with sequence similarity 50 member A
Synonyms

9F, DXS9928E, HXC-26, HXC26, MRXSA, XAP5
Links

HGNC:18786

NCBI Gene ID: 9130

neXtProt AC: NX_Q14320

UniProt: Q14320
Chr Location

Xq28; chrX:154444141-154450654 (+) GRCh38

MGI Vertebrate Homology

Fam50a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM50A
Gene Tree

Fam50a

Diseases

1 with human FAM50A associations

				Human Disease	Mouse Models
				Armfield syndrome IDs Armfield syndrome DOID:0050764 ICD10CM:Q87.8 OMIM:300261 ORDO:85276

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

4
Endonuclease-mediated

2
Gene trapped

1
Targeted

1
Find Mice (IMSR)

4 strains or lines available

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

15
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam50a

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All Sequences

35
RefSeq

4
UniProt

3
CCDS

CCDS41021.1

Ensembl

ENSMUSG00000001962 (Evidence)
NCBI Gene

108160

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001962	Ensembl Gene Model \| MGI Sequence Detail	7117	C57BL/6J	± kb
transcript	ENSMUST00000114160	Ensembl \| MGI Sequence Detail	1383	Not Applicable
polypeptide	ENSMUSP00000109797	Ensembl \| MGI Sequence Detail	339	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029476 protein FAM50A

(term hierarchy)
InterPro Domains

IPR048337 FAM50A/XAP5, C-terminal domain

IPR007005 XAP5 protein

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All nucleic 15

cDNA 15

Microarray probesets 3

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 5
Earliest

J:58261 Sedlacek Z, et al., Human and mouse XAP-5 and XAP-5-like (X5L) genes: identification of an ancient functional retroposon differentially expressed in testis. Genomics. 1999 Oct 15;61(2):125-32
Latest

J:357849 Wang W, et al., Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors. Elife. 2024;

TSS for Fam50a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161340	ChrX:73356620-73356715 (+)	29 bp
Tssr161341	ChrX:73356848-73356859 (+)	215 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24