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Sergef Gene Detail
Summary
  • Symbol
    Sergef
  • Name
    secretion regulating guanine nucleotide exchange factor
  • Synonyms
    DelGEF, Gef, Gnefr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351630
    NCBI Gene: 27414
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46092578-46289231 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.20 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6228 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351630
 protein coding gene Chr7:46092578-46289254 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032265
 protein coding gene Chr7:46815376-47023876 (-)
A/J MGP_AJ_G0032244
 protein coding gene Chr7:45849550-46046964 (-)
AKR/J MGP_AKRJ_G0032180
 protein coding gene Chr7:47146976-47348614 (-)
BALB/cJ MGP_BALBcJ_G0032256
 protein coding gene Chr7:45857262-46056538 (-)
C3H/HeJ MGP_C3HHeJ_G0031971
 protein coding gene Chr7:47642212-47843246 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032748
 protein coding gene Chr7:49088822-49292633 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029762
 protein coding gene Chr7:48401813-48604985 (-)
CAST/EiJ MGP_CASTEiJ_G0031299
 protein coding gene Chr7:39077517-39287639 (-)
CBA/J MGP_CBAJ_G0031936
 protein coding gene Chr7:50726086-50939998 (-)
DBA/2J MGP_DBA2J_G0032093
 protein coding gene Chr7:45545838-45741176 (-)
FVB/NJ MGP_FVBNJ_G0032045
 protein coding gene Chr7:45332499-45535674 (-)
LP/J MGP_LPJ_G0032172
 protein coding gene Chr7:47510134-47716455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032082
 protein coding gene Chr7:49361138-49560853 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032763
 protein coding gene Chr7:46359453-46564808 (-)
PWK/PhJ MGP_PWKPhJ_G0031022
 protein coding gene Chr7:38913697-39115928 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030860
 protein coding gene Chr7:34376631-34579694 (-)
WSB/EiJ MGP_WSBEiJ_G0031417
 protein coding gene Chr7:46861888-47068489 (-)



Homology
more
  • Human Ortholog
    SERGEF, secretion regulating guanine nucleotide exchange factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERGEF, secretion regulating guanine nucleotide exchange factor
  • Synonyms
    DELGEF, Gnefr
  • Links
    NCBI Gene ID: 26297
    neXtProt AC: NX_Q9UGK8
    UniProt: Q9UGK8

  • Chr Location
    11p15.1; chr11:17788048-18013047 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    9
  • cDNA Data
    22
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030839 Ensembl Gene Model | MGI Sequence Detail 196654 C57BL/6J ±  kb
transcript ENSMUST00000033127 Ensembl | MGI Sequence Detail 1465 Not Applicable  
polypeptide ENSMUSP00000033127 Ensembl | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014668 secretion-regulating guanine nucleotide exchange factor
    (term hierarchy)
  • InterPro Domains
    IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
    IPR000408 Regulator of chromosome condensation, RCC1
    IPR051210 Ubiquitin ligases and GEF domain-containing protein
  • GlyGen
    Q80YD6 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:58143 Uhlmann J, et al., DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. FEBS Lett. 1999 Oct 22;460(1):153-60
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory