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Abcc5 Gene Detail
Summary
  • Symbol
    Abcc5
  • Name
    ATP-binding cassette, sub-family C member 5
  • Synonyms
    2900011L11Rik, Abcc5a, Abcc5b, Mrp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351644
    NCBI Gene: 27416
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20150053-20245144 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2667 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351644
 protein coding gene Chr16:20150053-20245178 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022641
 protein coding gene Chr16:17646996-17748768 (-)
A/J MGP_AJ_G0022603
 protein coding gene Chr16:16804957-16899642 (-)
AKR/J MGP_AKRJ_G0022578
 protein coding gene Chr16:17445403-17547023 (-)
BALB/cJ MGP_BALBcJ_G0022607
 protein coding gene Chr16:16953093-17056185 (-)
C3H/HeJ MGP_C3HHeJ_G0022372
 protein coding gene Chr16:17603512-17701569 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023058
 protein coding gene Chr16:17981033-18095238 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020575
 protein coding gene Chr16:17490795-17586918 (-)
CAST/EiJ MGP_CASTEiJ_G0021902
 protein coding gene Chr16:17581481-17680095 (-)
CBA/J MGP_CBAJ_G0022344
 protein coding gene Chr16:18713511-18823009 (-)
DBA/2J MGP_DBA2J_G0022476
 protein coding gene Chr16:16732951-16828788 (-)
FVB/NJ MGP_FVBNJ_G0022451
 protein coding gene Chr16:16762745-16859656 (-)
LP/J MGP_LPJ_G0022543
 protein coding gene Chr16:17386875-17483426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022471
 protein coding gene Chr16:18421731-18527177 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023069
 protein coding gene Chr16:17398092-17499860 (-)
PWK/PhJ MGP_PWKPhJ_G0021643
 protein coding gene Chr16:16980472-17080055 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021472
 protein coding gene Chr16:17197302-17296632 (-)
WSB/EiJ MGP_WSBEiJ_G0021946
 protein coding gene Chr16:17394339-17492793 (-)



Homology
more
  • Human Ortholog
    ABCC5, ATP binding cassette subfamily C member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCC5, ATP binding cassette subfamily C member 5
  • Synonyms
    ABC33, EST277145, MOAT-C, MOATC, MRP5, pABC11, SMRP
  • Links
    NCBI Gene ID: 10057
    neXtProt AC: NX_O15440
    UniProt: O15440

  • Chr Location
    3q27.1; chr3:183919934-184017939 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display normal cGMP transport into erythrocyte membrane vesicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    110
  • cDNA Data
    122
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022822 Ensembl Gene Model | MGI Sequence Detail 95092 C57BL/6J ±  kb
    transcript ENSMUST00000079158 Ensembl | MGI Sequence Detail 5811 Not Applicable  
    polypeptide ENSMUSP00000078158 Ensembl | MGI Sequence Detail 1436 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      cDNA 126

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1351643, MGI:1925590, MGI:2146379
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:58835 Konig J, et al., Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta. 1999 Dec 6;1461(2):377-94
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory