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Yme1l1 Gene Detail
Summary
  • Symbol
    Yme1l1
  • Name
    YME1-like 1 (S. cerevisiae)
  • Synonyms
    ATP-dependent metalloprotease FtsH1, Ftsh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351651
    NCBI Gene: 27377
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:23046517-23089272 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 15.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1021 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351651
 protein coding gene Chr2:23046381-23089272 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025397
 protein coding gene Chr2:20902941-20948992 (+)
A/J MGP_AJ_G0025375
 protein coding gene Chr2:20061632-20103979 (+)
AKR/J MGP_AKRJ_G0025344
 protein coding gene Chr2:20774412-20818870 (+)
BALB/cJ MGP_BALBcJ_G0025370
 protein coding gene Chr2:20165549-20209064 (+)
C3H/HeJ MGP_C3HHeJ_G0025131
 protein coding gene Chr2:20690859-20735505 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025814
 protein coding gene Chr2:21502630-21553021 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0024594
 protein coding gene Chr2:20606251-20652259 (+)
CBA/J MGP_CBAJ_G0025109
 protein coding gene Chr2:22326258-22374668 (+)
DBA/2J MGP_DBA2J_G0025242
 protein coding gene Chr2:19949479-19992351 (+)
FVB/NJ MGP_FVBNJ_G0025204
 protein coding gene Chr2:19729547-19772503 (+)
LP/J MGP_LPJ_G0025328
 protein coding gene Chr2:20837922-20882682 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025235
 protein coding gene Chr2:22397913-22447576 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025873
 protein coding gene Chr2:20676096-20720614 (+)
PWK/PhJ MGP_PWKPhJ_G0024343
 protein coding gene Chr2:19779624-19824088 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024143
 protein coding gene Chr2:20775980-20815625 (+)
WSB/EiJ MGP_WSBEiJ_G0024664
 protein coding gene Chr2:20798687-20845111 (+)



Homology
more
  • Human Ortholog
    YME1L1, YME1 like 1 ATPase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YME1L1, YME1 like 1 ATPase
  • Synonyms
    FTSH, MEG4, OPA11, PAMP, YME1L
  • Links
    NCBI Gene ID: 10730
    neXtProt AC: NX_Q96TA2
    UniProt: Q96TA2

  • Chr Location
    10p12.1; chr10:27110111-27155266 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Yme1l1 mouse models; 1 with human YME1L1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die prior to E13.5, and show a developmental delay from E8.5 to E12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    140
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27377 NCBI Gene Model | MGI Sequence Detail 42756 C57BL/6J ±  kb
    transcript NM_013771 RefSeq | MGI Sequence Detail 4571 C57BL/6  
    polypeptide O88967 UniProt | EBI | MGI Sequence Detail 715 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 141
      cDNA 141

      Microarray probesets 8
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:62529 Coppola M, et al., Identification and characterization of YME1L1, a novel paraplegin-related gene. Genomics. 2000 May 15;66(1):48-54
    • Latest
      J:333724 Park EJ, et al., Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory