Abcf1 MGI Mouse Gene Detail - MGI:1351658 - ATP-binding cassette, sub-family F member 1

Symbol

Abcf1
Name

ATP-binding cassette, sub-family F member 1
Synonyms

Abc50, D17Wsu166e, GCN20

Feature Type

protein coding gene
IDs

MGI:1351658
NCBI Gene: 224742
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:36267711-36280642 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.80 cM
Mapping Data

5 experiments

SNPs within 2kb

3 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351658	protein coding gene	Chr17:36267711-36280653 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023663	protein coding gene	Chr17:36171656-36188285 (-)
A/J	MGP_AJ_G0023618	protein coding gene	Chr17:35046938-35059841 (-)
AKR/J	MGP_AKRJ_G0023588	protein coding gene	Chr17:35482513-35495459 (-)
BALB/cJ	MGP_BALBcJ_G0023623	protein coding gene	Chr17:35188449-35201288 (-)
C3H/HeJ	MGP_C3HHeJ_G0023389	protein coding gene	Chr17:35937800-35951729 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024065	protein coding gene	Chr17:37644915-37657930 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021545	protein coding gene	Chr17:33035747-33048420 (-)
CAST/EiJ	MGP_CASTEiJ_G0022880	protein coding gene	Chr17:36052621-36065461 (-)
CBA/J	MGP_CBAJ_G0023367	protein coding gene	Chr17:39232713-39245675 (-)
DBA/2J	MGP_DBA2J_G0023491	protein coding gene	Chr17:34342968-34355807 (-)
FVB/NJ	MGP_FVBNJ_G0023462	protein coding gene	Chr17:34140437-34153611 (-)
LP/J	MGP_LPJ_G0023571	protein coding gene	Chr17:36548421-36561404 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023483	protein coding gene	Chr17:37997097-38009976 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024108	protein coding gene	Chr17:35788221-35804047 (-)
PWK/PhJ	MGP_PWKPhJ_G0022631	protein coding gene	Chr17:33207754-33220928 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022450	protein coding gene	Chr17:33831205-33844001 (-)
WSB/EiJ	MGP_WSBEiJ_G0022946	protein coding gene	Chr17:35939290-35952124 (-)

Human Ortholog

ABCF1, ATP binding cassette subfamily F member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABCF1, ATP binding cassette subfamily F member 1
Synonyms

ABC27, ABC50
Links

HGNC:70

NCBI Gene ID: 23

neXtProt AC: NX_Q8NE71

UniProt: Q8NE71
Chr Location

6p21.33; chr6:30571393-30597179 (+) GRCh38

MGI Vertebrate Homology

Abcf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABCF1
Gene Tree

Abcf1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

2
Gene trapped

12
Targeted

5
Genomic Mutations

1 involving Abcf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available

Mice homozygous for a null allele display lethality shortly after implantation.

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

776
Tissues

56
cDNA Data

245
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase abcf1

ZFIN abcf1

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All Sequences

65
RefSeq

2
UniProt

8
CCDS

CCDS28713.1

Ensembl

ENSMUSG00000038762 (Evidence)
NCBI Gene

224742

			Length	Strain/Species	Flank
genomic	224742	NCBI Gene Model \| MGI Sequence Detail	12932	C57BL/6J	± kb
transcript	NM_013854	RefSeq \| MGI Sequence Detail	3207	Not Specified
polypeptide	Q6P542	UniProt \| EBI \| MGI Sequence Detail	837	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000003569 ATP-binding cassette sub-family F member 1

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003439 ABC transporter-like, ATP-binding domain

IPR017871 ABC transporter-like, conserved site

IPR050611 ATP-binding cassette sub-family F member, EF3 subfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q6P542 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 247

cDNA 245

Primer pair 1

Other 1

Microarray probesets 10

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MGD-MRK-36426, MGI:107849, MGI:2147001

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 13
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Abcf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147934	Chr17:36280616-36280677 (-)	-5 bp
Tssr147933	Chr17:36280589-36280603 (-)	46 bp
Tssr147932	Chr17:36280420-36280461 (-)	201 bp
Tssr147931	Chr17:36274554-36274569 (-)	6,080 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24