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Trpm2 Gene Detail
Summary
  • Symbol
    Trpm2
  • Name
    transient receptor potential cation channel, subfamily M, member 2
  • Synonyms
    9830168K16Rik, LTRPC2, TRPC7, Trrp7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351901
    NCBI Gene: 28240
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:77743556-77805746 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1703 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351901
 protein coding gene Chr10:77743556-77806397 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017411
 protein coding gene Chr10:78309169-78371850 (-)
A/J MGP_AJ_G0017389
 protein coding gene Chr10:75608187-75664709 (-)
AKR/J MGP_AKRJ_G0017352
 protein coding gene Chr10:77622002-77680141 (-)
BALB/cJ MGP_BALBcJ_G0017351
 protein coding gene Chr10:75774892-75832263 (-)
C3H/HeJ MGP_C3HHeJ_G0017174
 protein coding gene Chr10:77710124-77768222 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017807
 protein coding gene Chr10:81093594-81154552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015498
 protein coding gene Chr10:71953886-72015286 (-)
CAST/EiJ MGP_CASTEiJ_G0016744
 protein coding gene Chr10:78033712-78091480 (-)
CBA/J MGP_CBAJ_G0017146
 protein coding gene Chr10:84163662-84228302 (-)
DBA/2J MGP_DBA2J_G0017254
 protein coding gene Chr10:74842049-74897759 (-)
FVB/NJ MGP_FVBNJ_G0017246
 protein coding gene Chr10:74017006-74081398 (-)
LP/J MGP_LPJ_G0017325
 protein coding gene Chr10:78755342-78822254 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017273
 protein coding gene Chr10:86169830-86231933 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017849
 protein coding gene Chr10:77657687-77717010 (-)
PWK/PhJ MGP_PWKPhJ_G0016526
 protein coding gene Chr10:74726621-74782097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016311
 protein coding gene Chr10:76876064-76942100 (-)
WSB/EiJ MGP_WSBEiJ_G0016804
 protein coding gene Chr10:77639846-77701478 (-)



Homology
more
  • Human Ortholog
    TRPM2, transient receptor potential cation channel subfamily M member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPM2, transient receptor potential cation channel subfamily M member 2
  • Synonyms
    EREG1, KNP3, LTrpC-2, LTRPC2, NUDT9H, NUDT9L1, TRPC7
  • Links
    NCBI Gene ID: 7226
    neXtProt AC: NX_O94759
    UniProt: O94759

  • Chr Location
    21q22.3; chr21:44350163-44443081 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 6 alleles in 7 genetic backgrounds
    1 images
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    960
  • Tissues
    203
  • cDNA Data
    17
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28240 NCBI Gene Model | MGI Sequence Detail 62191 C57BL/6J ±  kb
    transcript NM_138301 RefSeq | MGI Sequence Detail 7292 ZRU/MplStud  
    polypeptide Q91YD4 UniProt | EBI | MGI Sequence Detail 1506 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 10
      cDNA 17
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143924, MGI:2444747
    References
    more
    • Summaries
      All 170
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 11
      Phenotypes 116
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory