Ilvbl MGI Mouse Gene Detail - MGI:1351911 - ilvB (bacterial acetolactate synthase)-like

Symbol

Ilvbl
Name

ilvB (bacterial acetolactate synthase)-like

Feature Type

protein coding gene
IDs

MGI:1351911
NCBI Gene: 216136
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:78410180-78420336 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

263 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351911	protein coding gene	Chr10:78410178-78420336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017425	protein coding gene	Chr10:79040924-79050661 (+)
A/J	MGP_AJ_G0017403	protein coding gene	Chr10:76285568-76295301 (+)
AKR/J	MGP_AKRJ_G0017366	protein coding gene	Chr10:78316532-78326337 (+)
BALB/cJ	MGP_BALBcJ_G0017365	protein coding gene	Chr10:76457570-76467299 (+)
C3H/HeJ	MGP_C3HHeJ_G0017188	protein coding gene	Chr10:78433802-78443542 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017821	protein coding gene	Chr10:81812300-81822033 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015512	protein coding gene	Chr10:72627876-72637961 (+)
CAST/EiJ	MGP_CASTEiJ_G0016758	protein coding gene	Chr10:78743238-78753240 (+)
CBA/J	MGP_CBAJ_G0017160	protein coding gene	Chr10:84946842-84956570 (+)
DBA/2J	MGP_DBA2J_G0017268	protein coding gene	Chr10:75521229-75530966 (+)
FVB/NJ	MGP_FVBNJ_G0017260	protein coding gene	Chr10:74703529-74713552 (+)
LP/J	MGP_LPJ_G0017339	protein coding gene	Chr10:79481762-79491509 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017287	protein coding gene	Chr10:86909239-86919234 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017863	protein coding gene	Chr10:78370683-78380421 (+)
PWK/PhJ	MGP_PWKPhJ_G0016540	protein coding gene	Chr10:75404527-75461694 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016325	protein coding gene	Chr10:77522962-77533104 (+)
WSB/EiJ	MGP_WSBEiJ_G0016818	protein coding gene	Chr10:78363647-78373642 (+)

Human Ortholog

ILVBL, ilvB acetolactate synthase like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ILVBL, ilvB acetolactate synthase like
Synonyms

209L8, AHAS, HACL1L, HACL2, ILV2H
Links

HGNC:6041

NCBI Gene ID: 10994

neXtProt AC: NX_A1L0T0

UniProt: A1L0T0
Chr Location

19p13.12; chr19:15114984-15125786 (-) GRCh38

MGI Vertebrate Homology

Ilvbl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ILVBL
Gene Tree

Ilvbl

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

2
Genomic Mutations

1 involving Ilvbl
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

52

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ilvbl

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All Sequences

97
RefSeq

14
UniProt

7
CCDS

CCDS23966.1, CCDS88046.1

Ensembl

ENSMUSG00000032763 (Evidence)
NCBI Gene

216136

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032763	Ensembl Gene Model \| MGI Sequence Detail	10157	C57BL/6J	± kb
transcript	ENSMUST00000105384	Ensembl \| MGI Sequence Detail	2329	Not Applicable
polypeptide	ENSMUSP00000101023	Ensembl \| MGI Sequence Detail	632	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000009011 2-hydroxyacyl-CoA lyase 2

(term hierarchy)
EC

4.1.2.-
InterPro Domains

IPR029035 DHS-like NAD/FAD-binding domain superfamily

IPR029061 Thiamin diphosphate-binding fold

IPR045229 Thiamine pyrophosphate enzyme

IPR012000 Thiamine pyrophosphate enzyme, central domain

IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain

IPR011766 Thiamine pyrophosphate enzyme, TPP-binding

IPR000399 TPP-binding enzyme, conserved site

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All nucleic 63

Genomic 11

cDNA 52

Microarray probesets 6

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MGI:2143590

Summaries

All 34

Gene Ontology 5

Phenotypes 9
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357542 Rhein S, et al., The reactive pyruvate metabolite dimethylglyoxal mediates neurological consequences of diabetes. Nat Commun. 2024 Jul 10;15(1):5745

TSS for Ilvbl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94336	Chr10:78410326-78410379 (+)	173 bp
Tssr94337	Chr10:78410824-78410897 (+)	681 bp
Tssr94338	Chr10:78410901-78410923 (+)	732 bp
Tssr94339	Chr10:78412810-78412827 (+)	2,639 bp
Tssr94340	Chr10:78412889-78412909 (+)	2,719 bp
Tssr94341	Chr10:78412928-78412944 (+)	2,756 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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