Abcc2 MGI Mouse Gene Detail - MGI:1352447 - ATP-binding cassette, sub-family member 2

Symbol

Abcc2
Name

ATP-binding cassette, sub-family member 2
Synonyms

Cmoat, Mrp2, multidrug resistance protein 2

Feature Type

protein coding gene
IDs

MGI:1352447
NCBI Gene: 12780
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr19:43770747-43826771 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 36.67 cM
Mapping Data

6 experiments

SNPs within 2kb

1543 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352447	protein coding gene	Chr19:43770631-43829179 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025158	protein coding gene	Chr19:43207809-43268587 (+)
A/J	MGP_AJ_G0025135	protein coding gene	Chr19:41151298-41212419 (+)
AKR/J	MGP_AKRJ_G0025103	protein coding gene	Chr19:42444102-42502525 (+)
BALB/cJ	MGP_BALBcJ_G0025129	protein coding gene	Chr19:41193994-41258179 (+)
C3H/HeJ	MGP_C3HHeJ_G0024889	protein coding gene	Chr19:42627558-42686129 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025572	protein coding gene	Chr19:44275721-44337063 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022986	protein coding gene	Chr19:40448787-40505975 (+)
CAST/EiJ	MGP_CASTEiJ_G0024354	protein coding gene	Chr19:42318983-42382498 (+)
CBA/J	MGP_CBAJ_G0024869	protein coding gene	Chr19:46468256-46534760 (+)
DBA/2J	MGP_DBA2J_G0025001	protein coding gene	Chr19:40973781-41038616 (+)
FVB/NJ	MGP_FVBNJ_G0024962	protein coding gene	Chr19:40728065-40788976 (+)
LP/J	MGP_LPJ_G0025087	protein coding gene	Chr19:43169346-43232669 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024993	protein coding gene	Chr19:46009428-46075350 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025630	protein coding gene	Chr19:42540851-42600959 (+)
PWK/PhJ	MGP_PWKPhJ_G0024103	protein coding gene	Chr19:40872263-40932061 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023907	protein coding gene	Chr19:41265303-41321726 (+)
WSB/EiJ	MGP_WSBEiJ_G0024424	protein coding gene	Chr19:42678836-42740186 (+)

Human Ortholog

ABCC2, ATP binding cassette subfamily C member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABCC2, ATP binding cassette subfamily C member 2
Synonyms

ABC30, CMOAT, cMRP, DJS, MRP2
Links

HGNC:53

NCBI Gene ID: 1244

neXtProt AC: NX_Q92887

UniProt: Q92887
Chr Location

10q24.2; chr10:99782640-99852594 (+) GRCh38

MGI Vertebrate Homology

Abcc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABCC2
Gene Tree

Abcc2

Diseases

8 with human ABCC2 associations

				Human Disease	Mouse Models
				acute lymphoblastic leukemia IDs acute lymphoblastic leukemia DOID:9952 EFO:0000220 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 NCI:C7055 OMIM:247640 OMIM:613065 ORDO:513 UMLS_CUI:C0023449 UMLS_CUI:C1335469
				bilirubin metabolic disorder IDs bilirubin metabolic disorder DOID:2741 DOID:2740 MESH:D006932 MESH:D006933 NCI:C84761 UMLS_CUI:C0020433 UMLS_CUI:C0020435
				cholangiocarcinoma IDs cholangiocarcinoma DOID:4947 DOID:5249 ICD10CM:C22.1 MESH:D018281 NCI:C4436 NCI:C8265 UMLS_CUI:C0206698 UMLS_CUI:C0280725
				chronic myeloid leukemia IDs chronic myeloid leukemia DOID:8552 DOID:8551 DOID:8606 EFO:0000339 ICD9CM:205.1 KEGG:05220 OMIM:608232 ORDO:521 UMLS_CUI:C0023473
				drug-induced hepatitis IDs drug-induced hepatitis DOID:2044 MESH:D056487 UMLS_CUI:C0524912
				Dubin-Johnson syndrome IDs Dubin-Johnson syndrome DOID:12308 ICD10CM:E80.6 MESH:D007566 NCI:C34741 OMIM:237500 UMLS_CUI:C0022350
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				metabolic dysfunction-associated steatotic liver disease IDs metabolic dysfunction-associated steatotic liver disease DOID:0080208 MESH:D065626 OMIM:613282 OMIM:613387

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 3 alleles in 5 genetic backgrounds
2 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

90 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have moderately enlarged livers, elevated plasma and urine bilirubin, and a reduced ability to clear various drugs and carcinogens from the blood.

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All GO Annotations

60
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

103
cDNA Data

29
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ABCC2

Xenbase abcc2

ZFIN abcc2

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All Sequences

39
RefSeq

4
UniProt

1
CCDS

CCDS29838.1

Ensembl

ENSMUSG00000025194 (Evidence)
NCBI Gene

12780

			Length	Strain/Species	Flank
genomic	12780	NCBI Gene Model \| MGI Sequence Detail	56025	C57BL/6J	± kb
transcript	NM_013806	RefSeq \| MGI Sequence Detail	5389	C57L/J
polypeptide	Q8VI47	UniProt \| EBI \| MGI Sequence Detail	1543	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003558 ATP-binding cassette sub-family C member 2

(term hierarchy)
GlyGen

Q8VI47 4 sites, 1 N-linked glycan (1 site)

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All nucleic 31

cDNA 29

Primer pair 2

Microarray probesets 3

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MGI:1196442, MGI:2147483

Summaries

All 76

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 21
Earliest

J:42393 Lammert F, et al., The gene encoding the multispecific organic anion transporter of the hepatocyte canalicular membraine (Cmoat) maps to mouse Chromosome 19. Mamm Genome. 1998 Jan;9(1):87-88
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Abcc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156533	Chr19:43770620-43770632 (+)	-121 bp
Tssr156534	Chr19:43770736-43770752 (+)	-3 bp
Tssr156535	Chr19:43770759-43770773 (+)	19 bp
Tssr156536	Chr19:43770778-43770789 (+)	37 bp
Tssr156537	Chr19:43771056-43771064 (+)	313 bp
Tssr156538	Chr19:43771480-43771490 (+)	738 bp
Tssr156539	Chr19:43775389-43775403 (+)	4,649 bp
Tssr156540	Chr19:43775410-43775420 (+)	4,668 bp
Tssr156541	Chr19:43775577-43775616 (+)	4,850 bp
Tssr156542	Chr19:43776544-43776555 (+)	5,803 bp
Tssr156543	Chr19:43776836-43776866 (+)	6,104 bp
Tssr156544	Chr19:43780822-43780837 (+)	10,083 bp
Tssr156545	Chr19:43782890-43782894 (+)	12,145 bp
Tssr156546	Chr19:43797203-43797218 (+)	26,464 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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