Cxcl9 MGI Mouse Gene Detail - MGI:1352449 - C-X-C motif chemokine ligand 9

Symbol

Cxcl9
Name

C-X-C motif chemokine ligand 9
Synonyms

CMK, crg-10, Mig, Scyb9

Feature Type

protein coding gene
IDs

MGI:1352449
NCBI Gene: 17329
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr5:92469206-92475938 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 46.51 cM
Mapping Data

6 experiments

SNPs within 2kb

299 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352449	protein coding gene	Chr5:92469190-92475938 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029748	protein coding gene	Chr5:93501538-93509633 (-)
A/J	MGP_AJ_G0029714	protein coding gene	Chr5:89787722-89794447 (-)
AKR/J	MGP_AKRJ_G0029660	protein coding gene	Chr5:92727263-92733940 (-)
BALB/cJ	MGP_BALBcJ_G0029724	protein coding gene	Chr5:90672575-90679252 (-)
C3H/HeJ	MGP_C3HHeJ_G0029447	protein coding gene	Chr5:93131302-93137979 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030178	protein coding gene	Chr5:97213374-97220106 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027414	protein coding gene	Chr5:85438707-85445306 (-)
CAST/EiJ	MGP_CASTEiJ_G0028857	protein coding gene	Chr5:92506726-92515558 (-)
CBA/J	MGP_CBAJ_G0029417	protein coding gene	Chr5:100587931-100594608 (-)
DBA/2J	MGP_DBA2J_G0029561	protein coding gene	Chr5:89835527-89842768 (-)
FVB/NJ	MGP_FVBNJ_G0029520	protein coding gene	Chr5:88680703-88687380 (-)
LP/J	MGP_LPJ_G0029649	protein coding gene	Chr5:93870395-93877053 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029549	protein coding gene	Chr5:105494358-105510205 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030212	protein coding gene	Chr5:92254388-92261121 (-)
PWK/PhJ	MGP_PWKPhJ_G0028576	protein coding gene	Chr5:88900525-88907211 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028411	protein coding gene	Chr5:91618426-91625077 (-)
WSB/EiJ	MGP_WSBEiJ_G0028936	protein coding gene	Chr5:92721671-92728348 (-)

Human Ortholog

CXCL9, C-X-C motif chemokine ligand 9

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXCL9, C-X-C motif chemokine ligand 9
Synonyms

CMK, crg-10, Humig, MIG, SCYB9
Links

HGNC:7098

NCBI Gene ID: 4283

neXtProt AC: NX_Q07325

UniProt: Q07325
Chr Location

4q21.1; chr4:76001275-76007509 (-) GRCh38

MGI Vertebrate Homology

Cxcl9 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: CXCL9
Gene Tree

Cxcl9

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

3 involving Cxcl9
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show a significant reduction in CD4+ T cell infiltration into the cornea in response to ocular HSV-1 infection, and produce lower titers of antibodies in response to primary infection with the intracellular bacterium Francisella tularensis live vaccine strain.

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

49
cDNA Data

80
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS39152.1

Ensembl

ENSMUSG00000029417 (Evidence)
NCBI Gene

17329

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029417	Ensembl Gene Model \| MGI Sequence Detail	6733	C57BL/6J	± kb
transcript	ENSMUST00000113093	Ensembl \| MGI Sequence Detail	2889	Not Applicable
polypeptide	ENSMUSP00000108716	Ensembl \| MGI Sequence Detail	126	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006073 C-X-C motif chemokine 9

(term hierarchy)
InterPro Domains

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

IPR001089 CXC chemokine

IPR018048 CXC chemokine, conserved site

IPR033899 CXC Chemokine domain
GlyGen

P18340 1 site

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All nucleic 84

Genomic 1

cDNA 80

Primer pair 3

Microarray probesets 3

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MGD-MRK-33048, MGI:105379, MGI:2141267

Summaries

All 127

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 38
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cxcl9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51876	Chr5:92475927-92475945 (-)	2 bp
Tssr51875	Chr5:92475901-92475924 (-)	25 bp
Tssr51874	Chr5:92474674-92474689 (-)	1,256 bp
Tssr1547	Chr5:92474661-92474662 (-)	1,276 bp
Tssr51873	Chr5:92474649-92474659 (-)	1,284 bp
Tssr51872	Chr5:92472971-92472993 (-)	2,956 bp
Tssr51871	Chr5:92471728-92471740 (-)	4,204 bp
Tssr51870	Chr5:92471694-92471705 (-)	4,238 bp
Tssr51869	Chr5:92471652-92471655 (-)	4,284 bp
Tssr51868	Chr5:92471606-92471613 (-)	4,328 bp
Tssr51867	Chr5:92471550-92471567 (-)	4,379 bp
Tssr51866	Chr5:92470958-92470965 (-)	4,976 bp
Tssr51865	Chr5:92470669-92470685 (-)	5,261 bp
Tssr51864	Chr5:92470591-92470601 (-)	5,342 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24