Nr4a1 Gene Detail

Summary

• Symbol
  Nr4a1
• Name
  nuclear receptor subfamily 4, group A, member 1
• Synonyms
  Gfrp, GFRP1, Hbr-1, Hbr1, Hmr, N10, NGFI-B, NP10, Nur77, TIS1, TR3

• Feature Type
  protein coding gene
• IDs
  MGI:1352454
  NCBI Gene: 15370
• Alliance
  gene page
• Transcription Start Sites
  71 TSS

Location &
Maps

• Sequence Map
  Chr15:101152150-101172676 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 56.64 cM, cytoband F
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  420 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352454	protein coding gene	Chr15:101151783-101172676 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022368	protein coding gene	Chr15:103314940-103322804 (+)
A/J	MGP_AJ_G0022330	protein coding gene	Chr15:99230474-99238344 (+)
AKR/J	MGP_AKRJ_G0022306	protein coding gene	Chr15:102255429-102266633 (+)
BALB/cJ	MGP_BALBcJ_G0022334	protein coding gene	Chr15:99332354-99340218 (+)
C3H/HeJ	MGP_C3HHeJ_G0022104	protein coding gene	Chr15:102340228-102348151 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022782	protein coding gene	Chr15:107157537-107165506 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020307	protein coding gene	Chr15:94965856-94973581 (+)
CAST/EiJ	MGP_CASTEiJ_G0021629	protein coding gene	Chr15:103191769-103199703 (+)
CBA/J	MGP_CBAJ_G0022073	protein coding gene	Chr15:110876572-110884436 (+)
DBA/2J	MGP_DBA2J_G0022200	protein coding gene	Chr15:98562172-98569994 (+)
FVB/NJ	MGP_FVBNJ_G0022179	protein coding gene	Chr15:97612575-97620838 (+)
LP/J	MGP_LPJ_G0022271	protein coding gene	Chr15:103457474-103465338 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022200	protein coding gene	Chr15:114566048-114573875 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022796	protein coding gene	Chr15:102280298-102288201 (+)
PWK/PhJ	MGP_PWKPhJ_G0021368	protein coding gene	Chr15:98718503-98726449 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021200	protein coding gene	Chr15:102177486-102185268 (+)
WSB/EiJ	MGP_WSBEiJ_G0021679	protein coding gene	Chr15:102901442-102909406 (+)

Homology

• Human Ortholog
  NR4A1, nuclear receptor subfamily 4 group A member 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  NR4A1, nuclear receptor subfamily 4 group A member 1
  
• Synonyms
  GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
• Links
  HGNC:7980

  NCBI Gene ID: 3164

  neXtProt AC: NX_P22736

  UniProt: P22736

  
  
• Chr Location
  12q13.13; chr12:52022832-52059507 (+)  GRCh38

---

• MGI Vertebrate Homology
  Nr4a1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: NR4A1
• Gene Tree
  Nr4a1
  

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 3 alleles in 6 genetic backgrounds
  25 phenotypes from multigenic genotypes
  162 phenotype references
  

• All Mutations and Alleles
  23
• Chemically induced (ENU)
  1
• Chemically induced (other)
  1
• Endonuclease-mediated
  4
• Gene trapped
  10
• Radiation induced
  2
• Targeted
  4
• Transgenic
  1
• Genomic Mutations
  3 involving Nr4a1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  39 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a targeted null mutation are viable, fertile, and display a normal HPA axis function, as well as normal thymic and peripheral T cell deletion. Homozygous KO decreases apoptosis and increases proliferation of B cell stimulated by a single antigen.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  85
• GO References
  26

Expression

• Assay Results
  896
• Tissues
  92
• cDNA Data
  66
• Literature Summary
  26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase nr4a1
  ZFIN nr4a1

Sequences &
Gene Models

• All Sequences
  59
• RefSeq
  18
• UniProt
  3
• CCDS
  CCDS27848.1

• Ensembl
  ENSMUSG00000023034 (Evidence)
• NCBI Gene
  15370

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000023034	Ensembl Gene Model | MGI Sequence Detail	20527	C57BL/6J
transcript	ENSMUST00000023779	Ensembl | MGI Sequence Detail	2477	Not Applicable
polypeptide	ENSMUSP00000023779	Ensembl | MGI Sequence Detail	601	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000011408 nuclear receptor subfamily 4 immunity group A member 1
  (term hierarchy)
• InterPro Domains
  IPR001723 Nuclear hormone receptor
  IPR000536 Nuclear hormone receptor, ligand-binding domain
  IPR035500 Nuclear hormone receptor-like domain superfamily
  IPR003071 Nuclear receptor subfamily 4 group A member 1
  IPR003070 Nuclear receptor subfamily 4 group A member 1-3
  IPR013088 Zinc finger, NHR/GATA-type
  IPR001628 Zinc finger, nuclear hormone receptor-type

Molecular
Reagents

• All nucleic 75

  Genomic 1

  cDNA 66

  Primer pair 5

  Other 3

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-10057, MGD-MRK-10641, MGD-MRK-10642, MGI:95699, MGI:96029

References

• Summaries
  All 296

  Developmental Gene Expression 26

  Diseases 2

  Gene Ontology 26

  Phenotypes 162
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:359351 Guo W, et al., Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease. Immunity. 2024 Oct 8;57(10):2310-2327.e6

TSS for Nr4a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133202	Chr15:101152081-101152210 (+)	-4 bp
Tssr133203	Chr15:101152367-101152378 (+)	223 bp
Tssr133204	Chr15:101152392-101152399 (+)	246 bp
Tssr133205	Chr15:101154266-101154274 (+)	2,120 bp
Tssr133206	Chr15:101154281-101154299 (+)	2,140 bp
Tssr133207	Chr15:101155116-101155133 (+)	2,975 bp
Tssr133208	Chr15:101156277-101156283 (+)	4,130 bp
Tssr133214	Chr15:101164720-101164740 (+)	12,580 bp
Tssr133215	Chr15:101164981-101164993 (+)	12,837 bp
Tssr133216	Chr15:101165009-101165024 (+)	12,867 bp
Tssr133217	Chr15:101165126-101165127 (+)	12,977 bp
Tssr133218	Chr15:101165735-101165755 (+)	13,595 bp
Tssr133219	Chr15:101165756-101165777 (+)	13,617 bp
Tssr133220	Chr15:101165865-101165872 (+)	13,719 bp
Tssr133221	Chr15:101165908-101165932 (+)	13,770 bp
Tssr133222	Chr15:101167268-101167297 (+)	15,133 bp
Tssr133223	Chr15:101167957-101167987 (+)	15,822 bp
Tssr133224	Chr15:101168000-101168005 (+)	15,853 bp
Tssr133225	Chr15:101168011-101168021 (+)	15,866 bp
Tssr133226	Chr15:101168032-101168039 (+)	15,886 bp
Tssr133227	Chr15:101168040-101168052 (+)	15,896 bp
Tssr133228	Chr15:101168058-101168068 (+)	15,913 bp
Tssr133229	Chr15:101168069-101168106 (+)	15,938 bp
Tssr133230	Chr15:101168147-101168165 (+)	16,006 bp
Tssr133231	Chr15:101168179-101168191 (+)	16,035 bp
Tssr133232	Chr15:101168198-101168218 (+)	16,058 bp
Tssr133233	Chr15:101168226-101168239 (+)	16,083 bp
Tssr133234	Chr15:101168244-101168265 (+)	16,105 bp
Tssr133235	Chr15:101168277-101168307 (+)	16,142 bp
Tssr133236	Chr15:101168326-101168346 (+)	16,186 bp
Tssr133237	Chr15:101168348-101168377 (+)	16,213 bp
Tssr133238	Chr15:101168381-101168395 (+)	16,238 bp
Tssr133239	Chr15:101168423-101168458 (+)	16,291 bp
Tssr133240	Chr15:101168515-101168526 (+)	16,371 bp
Tssr133241	Chr15:101168532-101168535 (+)	16,384 bp
Tssr133242	Chr15:101168540-101168547 (+)	16,394 bp
Tssr133243	Chr15:101168566-101168568 (+)	16,417 bp
Tssr133244	Chr15:101168587-101168598 (+)	16,443 bp
Tssr133245	Chr15:101168631-101168644 (+)	16,488 bp
Tssr133246	Chr15:101168656-101168674 (+)	16,515 bp
Tssr133247	Chr15:101168744-101168755 (+)	16,600 bp
Tssr133248	Chr15:101168764-101168773 (+)	16,619 bp
Tssr133249	Chr15:101169615-101169630 (+)	17,473 bp
Tssr133250	Chr15:101169649-101169660 (+)	17,505 bp
Tssr133251	Chr15:101169680-101169694 (+)	17,537 bp
Tssr133252	Chr15:101170027-101170037 (+)	17,882 bp
Tssr133253	Chr15:101170038-101170047 (+)	17,893 bp
Tssr133254	Chr15:101170058-101170083 (+)	17,921 bp
Tssr133255	Chr15:101170091-101170115 (+)	17,953 bp
Tssr133256	Chr15:101170132-101170145 (+)	17,989 bp
Tssr133257	Chr15:101170150-101170158 (+)	18,004 bp
Tssr133258	Chr15:101170602-101170617 (+)	18,460 bp
Tssr133259	Chr15:101170619-101170624 (+)	18,472 bp
Tssr133260	Chr15:101170637-101170644 (+)	18,491 bp
Tssr133261	Chr15:101170647-101170654 (+)	18,501 bp
Tssr133262	Chr15:101170658-101170666 (+)	18,512 bp
Tssr133263	Chr15:101170679-101170690 (+)	18,535 bp
Tssr133264	Chr15:101170698-101170707 (+)	18,553 bp
Tssr133265	Chr15:101170907-101170920 (+)	18,764 bp
Tssr133266	Chr15:101170932-101170939 (+)	18,786 bp
Tssr133267	Chr15:101170973-101170981 (+)	18,827 bp
Tssr133268	Chr15:101171020-101171038 (+)	18,879 bp
Tssr133269	Chr15:101171192-101171197 (+)	19,045 bp
Tssr133270	Chr15:101171854-101171864 (+)	19,709 bp
Tssr133271	Chr15:101171903-101171914 (+)	19,759 bp
Tssr133272	Chr15:101171963-101171968 (+)	19,816 bp
Tssr133273	Chr15:101172002-101172012 (+)	19,857 bp
Tssr133274	Chr15:101172069-101172080 (+)	19,925 bp
Tssr133275	Chr15:101172319-101172328 (+)	20,174 bp
Tssr133276	Chr15:101172481-101172491 (+)	20,336 bp
Tssr133277	Chr15:101172563-101172570 (+)	20,417 bp