Znhit2 Gene Detail

Summary

• Symbol
  Znhit2
• Name
  zinc finger, HIT domain containing 2
• Synonyms
  ORF6, Znhit2-ps

• Feature Type
  protein coding gene
• IDs
  MGI:1352481
  NCBI Gene: 29805
• Alliance
  gene page
• Transcription Start Sites
  9 TSS

Location &
Maps

• Sequence Map
  Chr19:6111237-6112498 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 4.34 cM, cytoband A
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  102 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352481	protein coding gene	Chr19:6111222-6112502 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024741	protein coding gene	Chr19:3090412-3091692 (+)
A/J	MGP_AJ_G0024707	protein coding gene	Chr19:2919377-2920657 (+)
AKR/J	MGP_AKRJ_G0024680	protein coding gene	Chr19:3010351-3011631 (+)
BALB/cJ	MGP_BALBcJ_G0024707	protein coding gene	Chr19:2914413-2915693 (+)
C3H/HeJ	MGP_C3HHeJ_G0024475	protein coding gene	Chr19:3029082-3030362 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025153	protein coding gene	Chr19:3147740-3149020 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022587	protein coding gene	Chr19:2848580-2849860 (+)
CAST/EiJ	MGP_CASTEiJ_G0023947	protein coding gene	Chr19:3035696-3036976 (+)
CBA/J	MGP_CBAJ_G0024447	protein coding gene	Chr19:3299147-3300427 (+)
DBA/2J	MGP_DBA2J_G0024574	protein coding gene	Chr19:2910142-2911422 (+)
FVB/NJ	MGP_FVBNJ_G0024540	protein coding gene	Chr19:2921264-2922544 (+)
LP/J	MGP_LPJ_G0024660	protein coding gene	Chr19:3068629-3069909 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024569	protein coding gene	Chr19:3119878-3121158 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025201	protein coding gene	Chr19:3040062-3041342 (+)
PWK/PhJ	MGP_PWKPhJ_G0023693	protein coding gene	Chr19:2938941-2940221 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023498	protein coding gene	Chr19:2998824-3000104 (+)
WSB/EiJ	MGP_WSBEiJ_G0024009	protein coding gene	Chr19:3047228-3048508 (+)

Homology

• Human Ortholog
  ZNHIT2, zinc finger HIT-type containing 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ZNHIT2, zinc finger HIT-type containing 2
  
• Synonyms
  C11orf5, FON
• Links
  HGNC:1177

  NCBI Gene ID: 741

  neXtProt AC: NX_Q9UHR6

  UniProt: Q9UHR6

  
  
• Chr Location
  11q13.1; chr11:65116403-65117701 (-)  GRCh38

---

• MGI Vertebrate Homology
  Znhit2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ZNHIT2
• Gene Tree
  Znhit2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  15 phenotypes from 1 allele in 1 genetic background
  1 images
  7 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  1
• Gene trapped
  2
• Find Mice (IMSR)
  12 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele show failure of in vitro blastocyst hatching and embryonic lethality during peri-implantation stages with fragmented DNA and abnormal inner cell mass, primitive endoderm, and trophectoderm morphology.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  735
• Tissues
  14
• cDNA Data
  58
• Literature Summary
  3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase znhit2
  ZFIN znhit2

Sequences &
Gene Models

• All Sequences
  37
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS57131.1

• Ensembl
  ENSMUSG00000075227 (Evidence)
• NCBI Gene
  29805

Representative Sequences			Length	Strain/Species
genomic	29805	NCBI Gene Model | MGI Sequence Detail	1262	C57BL/6J
transcript	NM_013859	RefSeq | MGI Sequence Detail	1262	C57BL/6
polypeptide	Q9QY66	UniProt | EBI | MGI Sequence Detail	399	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000031429 zinc finger HIT domain-containing protein 2
  (term hierarchy)
• InterPro Domains
  IPR039646 Zinc finger HIT domain-containing protein 2
  IPR007529 Zinc finger, HIT-type

Molecular
Reagents

• All nucleic 60

  cDNA 58

  Primer pair 1

  Other 1

  
  

  Microarray probesets 2

References

• Summaries
  All 29

  Developmental Gene Expression 3

  Gene Ontology 1

  Phenotypes 7
• Earliest
  J:59224 Lemmens IH, et al., Molecular characterization of human and murine C11orf5, a new member of the FAUNA gene cluster. Mamm Genome. 2000 Jan;11(1):78-80
• Latest
  J:354661 He XD, et al., Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development. Biol Reprod. 2024 Aug 28;

TSS for Znhit2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154551	Chr19:6111206-6111265 (+)	-1 bp
Tssr154552	Chr19:6111267-6111282 (+)	38 bp
Tssr154553	Chr19:6111297-6111318 (+)	71 bp
Tssr154554	Chr19:6111368-6111407 (+)	151 bp
Tssr154555	Chr19:6111414-6111425 (+)	183 bp
Tssr154556	Chr19:6111468-6111479 (+)	237 bp
Tssr154557	Chr19:6111496-6111509 (+)	266 bp
Tssr154558	Chr19:6111533-6111557 (+)	308 bp
Tssr154559	Chr19:6111560-6111592 (+)	339 bp