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Bag3 Gene Detail
Summary
  • Symbol
    Bag3
  • Name
    BCL2-associated athanogene 3
  • Synonyms
    Bcl-2-interacting death suppressor, Bis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352493
    NCBI Gene: 29810
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:128125340-128148705 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 70.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    558 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352493
 protein coding gene Chr7:128125307-128148705 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033084
 protein coding gene Chr7:132958712-132983489 (+)
A/J MGP_AJ_G0033066
 protein coding gene Chr7:129382638-129412031 (+)
AKR/J MGP_AKRJ_G0032998
 protein coding gene Chr7:132776917-132802183 (+)
BALB/cJ MGP_BALBcJ_G0033067
 protein coding gene Chr7:129046093-129069890 (+)
C3H/HeJ MGP_C3HHeJ_G0032781
 protein coding gene Chr7:132657925-132681575 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033577
 protein coding gene Chr7:138144384-138171367 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030549
 protein coding gene Chr7:130550565-130573242 (+)
CAST/EiJ MGP_CASTEiJ_G0032111
 protein coding gene Chr7:124445961-124471229 (+)
CBA/J MGP_CBAJ_G0032754
 protein coding gene Chr7:142874714-142903749 (+)
DBA/2J MGP_DBA2J_G0032906
 protein coding gene Chr7:127367989-127391439 (+)
FVB/NJ MGP_FVBNJ_G0032859
 protein coding gene Chr7:127233761-127257966 (+)
LP/J MGP_LPJ_G0033000
 protein coding gene Chr7:134432786-134458153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032891
 protein coding gene Chr7:143892163-143920909 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033596
 protein coding gene Chr7:131732537-131756844 (+)
PWK/PhJ MGP_PWKPhJ_G0031817
 protein coding gene Chr7:120383196-120406906 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031663
 protein coding gene Chr7:118541868-118565127 (+)
WSB/EiJ MGP_WSBEiJ_G0032222
 protein coding gene Chr7:132709163-132733325 (+)



Homology
more
  • Human Ortholog
    BAG3, BAG cochaperone 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAG3, BAG cochaperone 3
  • Synonyms
    BAG-3, BIS, CAIR-1, MFM6
  • Links
    NCBI Gene ID: 9531
    neXtProt AC: NX_O95817
    UniProt: O95817

  • Chr Location
    10q26.11; chr10:119651380-119677819 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Bag3 mouse models; 2 with human BAG3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 6 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    4 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit postnatal lethality, growth retardation, cardiomyocyte and skeletal myocyte degeneration, and pulmonary edema. Mice homozygous for a null allele also exhibit postnatal lethality and growth retardation but lack the myocyte degeneration phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    38
  • cDNA Data
    60
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030847 Ensembl Gene Model | MGI Sequence Detail 23366 C57BL/6J ±  kb
    transcript ENSMUST00000033136 Ensembl | MGI Sequence Detail 2562 Not Applicable  
    polypeptide ENSMUSP00000033136 Ensembl | MGI Sequence Detail 577 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141804
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 12
      Phenotypes 33
    • Earliest
      J:58551 Lee JH, et al., Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene. 1999 Nov 4;18(46):6183-90
    • Latest
      J:347066 Lin H, et al., BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1. Autophagy. 2024 Mar;20(3):577-589
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory