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Hspb7 Gene Detail
Summary
  • Symbol
    Hspb7
  • Name
    heat shock protein family, member 7 (cardiovascular)
  • Synonyms
    cvHsp, Hsp25-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352494
    NCBI Gene: 29818
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141148090-141152621 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.08 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352494
 protein coding gene Chr4:141148090-141152622 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029047
 protein coding gene Chr4:144477049-144481533 (+)
A/J MGP_AJ_G0029006
 protein coding gene Chr4:138189707-138194235 (+)
AKR/J MGP_AKRJ_G0028958
 protein coding gene Chr4:142175899-142180423 (+)
BALB/cJ MGP_BALBcJ_G0029030
 protein coding gene Chr4:138883055-138887569 (+)
C3H/HeJ MGP_C3HHeJ_G0028744
 protein coding gene Chr4:142554614-142559144 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029471
 protein coding gene Chr4:149507528-149512046 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026742
 protein coding gene Chr4:131104724-131109201 (+)
CAST/EiJ MGP_CASTEiJ_G0028176
 protein coding gene Chr4:140825686-140829269 (+)
CBA/J MGP_CBAJ_G0028708
 protein coding gene Chr4:153865782-153870308 (+)
DBA/2J MGP_DBA2J_G0028858
 protein coding gene Chr4:138592253-138596751 (+)
FVB/NJ MGP_FVBNJ_G0028825
 protein coding gene Chr4:137704846-137709336 (+)
LP/J MGP_LPJ_G0028957
 protein coding gene Chr4:144496907-144501375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028851
 protein coding gene Chr4:157678767-157683267 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029509
 protein coding gene Chr4:142715676-142720176 (+)
PWK/PhJ MGP_PWKPhJ_G0027897
 protein coding gene Chr4:135478879-135482536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027722
 protein coding gene Chr4:138520367-138524833 (+)
WSB/EiJ MGP_WSBEiJ_G0028254
 protein coding gene Chr4:142990628-142995132 (+)



Homology
more
  • Human Ortholog
    HSPB7, heat shock protein family B (small) member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPB7, heat shock protein family B (small) member 7
  • Synonyms
    cvHSP
  • Links
    NCBI Gene ID: 27129
    neXtProt AC: NX_Q9UBY9
    UniProt: Q9UBY9

  • Chr Location
    1p36.13; chr1:16014028-16019594 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    7 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic lethality during organogenesis and defects in heart development associated with increased thin filament length and formation of atypical actin filament bundles in cardiomyocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    95
  • cDNA Data
    48
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29818 NCBI Gene Model | MGI Sequence Detail 4532 C57BL/6J ±  kb
    transcript NM_013868 RefSeq | MGI Sequence Detail 2768 C57BL/6  
    polypeptide P35385 UniProt | EBI | MGI Sequence Detail 169 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:58297 Lowell BB, PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function. Cell. 1999 Oct 29;99(3):239-42
    • Latest
      J:334092 Broadway-Stringer S, et al., Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2. Cells. 2023 Feb 24;12(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory