Bcar3 MGI Mouse Gene Detail - MGI:1352501 - breast cancer anti-estrogen resistance 3

Symbol

Bcar3
Name

breast cancer anti-estrogen resistance 3
Synonyms

AND-34

Feature Type

protein coding gene
IDs

MGI:1352501
NCBI Gene: 29815
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr3:122213406-122323840 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 53.41 cM, cytoband G3
Mapping Data

3 experiments

SNPs within 2kb

3465 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352501	protein coding gene	Chr3:122087785-122323840 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027839	protein coding gene	Chr3:124553490-124806610 (+)
A/J	MGP_AJ_G0027797	protein coding gene	Chr3:120384192-120624219 (+)
AKR/J	MGP_AKRJ_G0027763	protein coding gene	Chr3:123449395-123694994 (+)
BALB/cJ	MGP_BALBcJ_G0027809	protein coding gene	Chr3:120191862-120433344 (+)
C3H/HeJ	MGP_C3HHeJ_G0027540	protein coding gene	Chr3:123847782-124094934 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028255	protein coding gene	Chr3:129210376-129325637 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025594	protein coding gene	Chr3:115809489-116050125 (+)
CAST/EiJ	MGP_CASTEiJ_G0026996	protein coding gene	Chr3:123232537-123489459 (+)
CBA/J	MGP_CBAJ_G0027515	protein coding gene	Chr3:133445506-133705293 (+)
DBA/2J	MGP_DBA2J_G0027656	protein coding gene	Chr3:119519875-119759148 (+)
FVB/NJ	MGP_FVBNJ_G0027624	protein coding gene	Chr3:117130850-117371715 (+)
LP/J	MGP_LPJ_G0027766	protein coding gene	Chr3:126067781-126320604 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027654	protein coding gene	Chr3:141006825-141257263 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028311	protein coding gene	Chr3:123006649-123258467 (+)
PWK/PhJ	MGP_PWKPhJ_G0026722	protein coding gene	Chr3:119220385-119468720 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0027076	protein coding gene	Chr3:123734880-123985128 (+)

Human Ortholog

BCAR3, BCAR3 adaptor protein, NSP family member

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCAR3, BCAR3 adaptor protein, NSP family member
Synonyms

AND-34, MIG7, NSP2, SH2D3B
Links

HGNC:973

NCBI Gene ID: 8412

neXtProt AC: NX_O75815

UniProt: O75815
Chr Location

1p22.1; chr1:93561741-93848151 (-) GRCh38

MGI Vertebrate Homology

Bcar3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BCAR3
Gene Tree

Bcar3

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References

1 with disease annotations

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

22
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

2 involving Bcar3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit cataracts due to rupture of the lens capsule and liquefaction of lens cortical fibers.

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All GO Annotations

28
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

22
cDNA Data

57
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bcar3

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All Sequences

53
RefSeq

6
UniProt

5
CCDS

CCDS17810.1

Ensembl

ENSMUSG00000028121 (Evidence)
NCBI Gene

29815

			Length	Strain/Species	Flank
genomic	29815	NCBI Gene Model \| MGI Sequence Detail	110435	C57BL/6J	± kb
transcript	NM_013867	RefSeq \| MGI Sequence Detail	3332	C57BL/6
polypeptide	Q9QZK2	UniProt \| EBI \| MGI Sequence Detail	820	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004677 breast cancer anti-estrogen resistance protein 3

(term hierarchy)
InterPro Domains

IPR051853 Adapter protein with SH2 and Ras-GEF domains

IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily

IPR023578 Ras guanine nucleotide exchange factor domain superfamily

IPR001895 Ras guanine-nucleotide exchange factors catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR044102 SHEP1/BCAR3/NSP1, SH2 domain
GlyGen

Q9QZK2 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 61

cDNA 58

Primer pair 3

Microarray probesets 3

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MGI:2139634

Summaries

All 49

Developmental Gene Expression 3

Diseases 1

Gene Ontology 10

Phenotypes 17
Earliest

J:56740 Cai D, et al., AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. J Immunol. 1999 Aug 15;163(4):2104-12
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bcar3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31494	Chr3:122213388-122213403 (+)	-10 bp
Tssr31495	Chr3:122213421-122213436 (+)	23 bp
Tssr31496	Chr3:122213442-122213455 (+)	43 bp
Tssr31497	Chr3:122213515-122213521 (+)	112 bp
Tssr31498	Chr3:122213634-122213649 (+)	236 bp
Tssr31499	Chr3:122277420-122277443 (+)	64,026 bp
Tssr31500	Chr3:122298308-122298315 (+)	84,906 bp
Tssr31501	Chr3:122304527-122304531 (+)	91,123 bp
Tssr31502	Chr3:122304848-122304869 (+)	91,453 bp
Tssr31503	Chr3:122304921-122304933 (+)	91,521 bp
Tssr31504	Chr3:122305604-122305607 (+)	92,200 bp
Tssr31505	Chr3:122305819-122305855 (+)	92,431 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24