Nkx6-2 MGI Mouse Gene Detail - MGI:1352738

Symbol

Nkx6-2
Name

NK6 homeobox 2
Synonyms

Gtx, Nkx6.2

Feature Type

protein coding gene
IDs

MGI:1352738
NCBI Gene: 14912
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:139159292-139162713 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.57 cM
Mapping Data

2 experiments

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352738	protein coding gene	Chr7:139159292-139162726 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033151	protein coding gene	Chr7:144609782-144613202 (-)
A/J	MGP_AJ_G0033133	protein coding gene	Chr7:140525289-140528709 (-)
AKR/J	MGP_AKRJ_G0033065	protein coding gene	Chr7:144330754-144334170 (-)
BALB/cJ	MGP_BALBcJ_G0033134	protein coding gene	Chr7:140267028-140270448 (-)
C3H/HeJ	MGP_C3HHeJ_G0032848	protein coding gene	Chr7:144142100-144145520 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033645	protein coding gene	Chr7:149946620-149950041 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030618	protein coding gene	Chr7:141656551-141659989 (-)
CAST/EiJ	MGP_CASTEiJ_G0032178	protein coding gene	Chr7:136433008-136436434 (-)
CBA/J	MGP_CBAJ_G0032821	protein coding gene	Chr7:155007243-155010663 (-)
DBA/2J	MGP_DBA2J_G0032973	protein coding gene	Chr7:138481025-138484445 (-)
FVB/NJ	MGP_FVBNJ_G0032926	protein coding gene	Chr7:138365190-138368610 (-)
LP/J	MGP_LPJ_G0033067	protein coding gene	Chr7:146159442-146162862 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032958	protein coding gene	Chr7:155698323-155701743 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033665	protein coding gene	Chr7:143321403-143324824 (-)
PWK/PhJ	MGP_PWKPhJ_G0031884	protein coding gene	Chr7:131652466-131655882 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031729	protein coding gene	Chr7:130158244-130161679 (-)
WSB/EiJ	MGP_WSBEiJ_G0032289	protein coding gene	Chr7:144238295-144241715 (-)

Human Ortholog

NKX6-2, NK6 homeobox 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NKX6-2, NK6 homeobox 2
Synonyms

GTX, NKX6.2, NKX6B, SPAX8
Links

HGNC:19321

NCBI Gene ID: 84504

neXtProt AC: NX_Q9C056

UniProt: Q9C056
Chr Location

10q26.3; chr10:132783179-132786147 (-) GRCh38

MGI Vertebrate Homology

Nkx6-2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NKX6-2
Gene Tree

Nkx6-2

Diseases

1 with human NKX6-2 associations

				Human Disease	Mouse Models
				spastic ataxia 8 IDs spastic ataxia 8 DOID:0080252 OMIM:617560

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 4 alleles in 4 genetic backgrounds
7 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Radiation induced

1
Targeted

7
Genomic Mutations

1 involving Nkx6-2
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired coordination at 6 weeks of age and axon degeneration in the optic nerve at 7 months of age.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

929
Tissues

120
cDNA Data

9
Literature Summary

75

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NKX6-2

Xenbase nkx6-2

ZFIN nkx6.2

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All Sequences

39
RefSeq

7
UniProt

2
CCDS

CCDS40170.1

Ensembl

ENSMUSG00000041309 (Evidence)
NCBI Gene

14912

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041309	Ensembl Gene Model \| MGI Sequence Detail	3422	C57BL/6J	± kb
transcript	ENSMUST00000097974	Ensembl \| MGI Sequence Detail	1907	Not Applicable
polypeptide	ENSMUSP00000095588	Ensembl \| MGI Sequence Detail	277	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR050394 Homeobox NK-like transcription regulators

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All nucleic 18

Genomic 2

cDNA 10

Primer pair 2

Other 4

Microarray probesets 4

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MGD-MRK-10330, MGI:95870

Summaries

All 116

Developmental Gene Expression 75

Gene Ontology 9

Phenotypes 29
Earliest

J:4385 Komuro I, et al., Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 1993 Apr;12(4):1387-401
Latest

J:354217 Ohyama K, et al., Differentiation stage-specific expression of transcriptional regulators for epithelial mesenchymal transition in dentate granule progenitors. Front Neurosci. 2024;18:1425849

TSS for Nkx6-2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75444	Chr7:139162708-139162724 (-)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24