Fscn1 MGI Mouse Gene Detail - MGI:1352745 - fascin actin-bundling protein 1

Symbol

Fscn1
Name

fascin actin-bundling protein 1
Synonyms

Fan1, fascin-1

Feature Type

protein coding gene
IDs

MGI:1352745
NCBI Gene: 14086
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr5:142946110-142958944 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 81.84 cM
Mapping Data

5 experiments

SNPs within 2kb

419 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352745	protein coding gene	Chr5:142946098-142958944 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030320	protein coding gene	Chr5:148260458-148275004 (+)
A/J	MGP_AJ_G0030289	protein coding gene	Chr5:141896057-141909556 (+)
AKR/J	MGP_AKRJ_G0030221	protein coding gene	Chr5:146321233-146334867 (+)
BALB/cJ	MGP_BALBcJ_G0030306	protein coding gene	Chr5:143142204-143154986 (+)
C3H/HeJ	MGP_C3HHeJ_G0030017	protein coding gene	Chr5:147143621-147156587 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030751	protein coding gene	Chr5:153665851-153682780 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027969	protein coding gene	Chr5:135695577-135709503 (+)
CAST/EiJ	MGP_CASTEiJ_G0029422	protein coding gene	Chr5:146628499-146648989 (+)
CBA/J	MGP_CBAJ_G0029987	protein coding gene	Chr5:159978184-159990803 (+)
DBA/2J	MGP_DBA2J_G0030137	protein coding gene	Chr5:141658060-141670784 (+)
FVB/NJ	MGP_FVBNJ_G0030092	protein coding gene	Chr5:140866746-140879408 (+)
LP/J	MGP_LPJ_G0030223	protein coding gene	Chr5:148862648-148875442 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030123	protein coding gene	Chr5:162445878-162459141 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030791	protein coding gene	Chr5:146184455-146197207 (+)
PWK/PhJ	MGP_PWKPhJ_G0029137	protein coding gene	Chr5:140746484-140759892 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028973	protein coding gene	Chr5:143932212-143959517 (+)
WSB/EiJ	MGP_WSBEiJ_G0029496	protein coding gene	Chr5:146979096-146993599 (+)

Human Ortholog

FSCN1, fascin actin-bundling protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FSCN1, fascin actin-bundling protein 1
Synonyms

FAN1, HSN, p55, SNL
Links

HGNC:11148

NCBI Gene ID: 6624

neXtProt AC: NX_Q16658

UniProt: Q16658
Chr Location

7p22.1; chr7:5592816-5606655 (+) GRCh38

MGI Vertebrate Homology

Fscn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FSCN1
Protein SuperFamily

Fascin
Gene Tree

Fscn1

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Phenotype Summary

26 phenotypes from 2 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

3
Gene trapped

9
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele show partial neonatal lethality, smaller size, enlarged lateral ventricles, abnormal anterior commissure pars posterior morphology, impaired migration of mature dendritic cells, and hypopigmentation due to migration and cell cycle defects in melanoblasts.

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All GO Annotations

85
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1059
Tissues

228
cDNA Data

18
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fscn1

ZFIN fscn1a, fscn1b

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All Sequences

55
RefSeq

2
UniProt

3
CCDS

CCDS19834.1

Ensembl

ENSMUSG00000029581 (Evidence)
NCBI Gene

14086

			Length	Strain/Species	Flank
genomic	14086	NCBI Gene Model \| MGI Sequence Detail	12835	C57BL/6J	± kb
transcript	NM_007984	RefSeq \| MGI Sequence Detail	2667	ZRU/MplStud
polypeptide	Q61553	UniProt \| EBI \| MGI Sequence Detail	493	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007677 fascin

(term hierarchy)
InterPro Domains

IPR008999 Actin-crosslinking

IPR010431 Fascin

IPR022768 Fascin domain

IPR024703 Fascin, metazoans
GlyGen

Q61553 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 18

Primer pair 3

Other 1

Microarray probesets 8

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MGD-MRK-36269, MGI:107693, MGI:2140957

Summaries

All 77

Developmental Gene Expression 13

Gene Ontology 17

Phenotypes 22
Earliest

J:25101 Edwards RA, et al., Cloning and expression of a murine fascin homolog from mouse brain. J Biol Chem. 1995 May 5;270(18):10764-70
Latest

J:347974 Zhou B, et al., Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Dev Cell. 2024 Apr 15;

TSS for Fscn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49613	Chr5:142946103-142946118 (+)	1 bp
Tssr49614	Chr5:142946232-142946248 (+)	130 bp
Tssr49615	Chr5:142946713-142946745 (+)	619 bp
Tssr49616	Chr5:142946755-142946775 (+)	655 bp
Tssr49617	Chr5:142946943-142946955 (+)	839 bp
Tssr49618	Chr5:142949433-142949444 (+)	3,329 bp
Tssr49619	Chr5:142956269-142956281 (+)	10,165 bp
Tssr49620	Chr5:142956296-142956317 (+)	10,197 bp
Tssr49621	Chr5:142956324-142956347 (+)	10,226 bp
Tssr49622	Chr5:142957842-142957855 (+)	11,739 bp
Tssr49623	Chr5:142957870-142957888 (+)	11,769 bp
Tssr49624	Chr5:142957997-142958013 (+)	11,895 bp
Tssr49625	Chr5:142958048-142958066 (+)	11,947 bp
Tssr49626	Chr5:142958090-142958109 (+)	11,990 bp
Tssr49627	Chr5:142958122-142958148 (+)	12,025 bp
Tssr49628	Chr5:142958170-142958188 (+)	12,069 bp
Tssr49629	Chr5:142958195-142958251 (+)	12,113 bp
Tssr49630	Chr5:142958439-142958481 (+)	12,350 bp
Tssr49631	Chr5:142958529-142958536 (+)	12,423 bp
Tssr49632	Chr5:142958599-142958625 (+)	12,502 bp
Tssr49633	Chr5:142958634-142958647 (+)	12,531 bp
Tssr49634	Chr5:142958782-142958806 (+)	12,684 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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