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Ninj2 Gene Detail
Summary
  • Symbol
    Ninj2
  • Name
    ninjurin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352751
    NCBI Gene: 29862
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:120070315-120177300 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.90 cM, cytoband F1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3090 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352751
 protein coding gene Chr6:120070311-120177300 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031199
 protein coding gene Chr6:122964245-123072623 (+)
A/J MGP_AJ_G0031168
 protein coding gene Chr6:118228486-118341283 (+)
AKR/J MGP_AKRJ_G0031099
 protein coding gene Chr6:121409444-121522442 (+)
BALB/cJ MGP_BALBcJ_G0031179
 protein coding gene Chr6:118003997-118106860 (+)
C3H/HeJ MGP_C3HHeJ_G0030530
 protein coding gene Chr6:62780680-62894678 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031637
 protein coding gene Chr6:126083410-126215071 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030286
 protein coding gene Chr6:121856699-121961812 (+)
CBA/J MGP_CBAJ_G0030862
 protein coding gene Chr6:131107463-131226335 (+)
DBA/2J MGP_DBA2J_G0031018
 protein coding gene Chr6:117127599-117229977 (+)
FVB/NJ MGP_FVBNJ_G0030970
 protein coding gene Chr6:116244679-116354417 (+)
LP/J MGP_LPJ_G0031097
 protein coding gene Chr6:122953914-123066205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031004
 protein coding gene Chr6:135123502-135235625 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031666
 protein coding gene Chr6:121446197-121553256 (+)
PWK/PhJ MGP_PWKPhJ_G0030001
 protein coding gene Chr6:116154116-116265594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029830
 protein coding gene Chr6:120170828-120272144 (+)
WSB/EiJ MGP_WSBEiJ_G0030369
 protein coding gene Chr6:121728293-121844922 (+)



Homology
more
  • Human Ortholog
    NINJ2, ninjurin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NINJ2, ninjurin 2
  • Links
    NCBI Gene ID: 4815
    neXtProt AC: NX_Q9NZG7
    UniProt: Q9NZG7

  • Chr Location
    12p13.33; chr12:564296-663589 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show impaired adipogenesis, increased insulin resistance and abnormal glucose homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29862 NCBI Gene Model | MGI Sequence Detail 106986 C57BL/6J ±  kb
    transcript NM_016718 RefSeq | MGI Sequence Detail 849 C57BL/6  
    polypeptide Q9JL89 UniProt | EBI | MGI Sequence Detail 143 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:59126 Araki T, et al., Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. J Neurosci. 2000 Jan 1;20(1):187-95
    • Latest
      J:352260 Zhang J, et al., Ninjurin 2, a Cell Adhesion Molecule and a Target of p53, Modulates Wild-Type p53 in Growth Suppression and Mutant p53 in Growth Promotion. Cancers (Basel). 2024 Jan 4;16(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory