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Pde7b Gene Detail
Summary
  • Symbol
    Pde7b
  • Name
    phosphodiesterase 7B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352752
    NCBI Gene: 29863
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:20273750-20600824 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 9.75 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352752
 protein coding gene Chr10:20272798-20600824 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017056
 protein coding gene Chr10:18145587-18496411 (-)
A/J MGP_AJ_G0017034
 protein coding gene Chr10:17451827-17780408 (-)
AKR/J MGP_AKRJ_G0016998
 protein coding gene Chr10:17769570-18097857 (-)
BALB/cJ MGP_BALBcJ_G0016992
 protein coding gene Chr10:17520321-17843835 (-)
C3H/HeJ MGP_C3HHeJ_G0016817
 protein coding gene Chr10:18082972-18421322 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017454
 protein coding gene Chr10:18595513-18942529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015159
 protein coding gene Chr10:16449496-16767380 (-)
CAST/EiJ MGP_CASTEiJ_G0016399
 protein coding gene Chr10:17961235-18315283 (-)
CBA/J MGP_CBAJ_G0016789
 protein coding gene Chr10:19435300-19815698 (-)
DBA/2J MGP_DBA2J_G0016897
 protein coding gene Chr10:17337570-17659964 (-)
FVB/NJ MGP_FVBNJ_G0016892
 protein coding gene Chr10:17088023-17410608 (-)
LP/J MGP_LPJ_G0016972
 protein coding gene Chr10:17949639-18295984 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016922
 protein coding gene Chr10:19678529-20037197 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017492
 protein coding gene Chr10:17752107-18084794 (-)
PWK/PhJ MGP_PWKPhJ_G0016184
 protein coding gene Chr10:17218502-17550957 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015967
 protein coding gene Chr10:17860415-18244329 (-)
WSB/EiJ MGP_WSBEiJ_G0016461
 protein coding gene Chr10:17832033-18175984 (-)



Homology
more
  • Human Ortholog
    PDE7B, phosphodiesterase 7B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE7B, phosphodiesterase 7B
  • Synonyms
    bA472E5.1
  • Links
    NCBI Gene ID: 27115
    neXtProt AC: NX_Q9NP56
    UniProt: Q9NP56

  • Chr Location
    6q23.3; chr6:135851701-136195574 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal response to ovalbumin-induced asthma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    136
  • cDNA Data
    8
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019990 Ensembl Gene Model | MGI Sequence Detail 327075 C57BL/6J ±  kb
    transcript ENSMUST00000169404 Ensembl | MGI Sequence Detail 1697 Not Applicable  
    polypeptide ENSMUSP00000132378 Ensembl | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000012485 3',5'-cyclic-AMP phosphodiesterase 7B
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.53
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003607 HD/PDEase domain
    • GlyGen
      Q9QXQ1 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory