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Aldh3a2 Gene Detail
Summary
  • Symbol
    Aldh3a2
  • Name
    aldehyde dehydrogenase family 3, subfamily A2
  • Synonyms
    Ahd-3, Ahd3, Ahd3-r, Ahd-3r, Aldh4, Aldh4-r, FALDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353452
    NCBI Gene: 11671
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61114240-61158267 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1384 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353452
 protein coding gene Chr11:61114240-61158290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018435
 protein coding gene Chr11:61174014-61219738 (-)
A/J MGP_AJ_G0018404
 protein coding gene Chr11:58914943-58959166 (-)
AKR/J MGP_AKRJ_G0018374
 protein coding gene Chr11:60757129-60806175 (-)
BALB/cJ MGP_BALBcJ_G0018375
 protein coding gene Chr11:59218149-59263040 (-)
C3H/HeJ MGP_C3HHeJ_G0018188
 protein coding gene Chr11:60732718-60777630 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018827
 protein coding gene Chr11:63108903-63152821 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016473
 protein coding gene Chr11:56053119-56094162 (-)
CAST/EiJ MGP_CASTEiJ_G0017745
 protein coding gene Chr11:60840643-60885127 (-)
CBA/J MGP_CBAJ_G0018162
 protein coding gene Chr11:65851901-65905982 (-)
DBA/2J MGP_DBA2J_G0018271
 protein coding gene Chr11:58497325-58540611 (-)
FVB/NJ MGP_FVBNJ_G0018262
 protein coding gene Chr11:58173115-58216069 (-)
LP/J MGP_LPJ_G0018344
 protein coding gene Chr11:61747966-61793915 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018286
 protein coding gene Chr11:66882258-66931058 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018868
 protein coding gene Chr11:60884201-60930820 (-)
PWK/PhJ MGP_PWKPhJ_G0017518
 protein coding gene Chr11:59094951-59137690 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017308
 protein coding gene Chr11:60702153-60744477 (-)
WSB/EiJ MGP_WSBEiJ_G0017797
 protein coding gene Chr11:60497973-60547956 (-)



Homology
more
  • Human Ortholog
    ALDH3A2, aldehyde dehydrogenase 3 family member A2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDH3A2, aldehyde dehydrogenase 3 family member A2
  • Synonyms
    ALDH10, FALDH, SLS
  • Links
    NCBI Gene ID: 224
    neXtProt AC: NX_P51648
    UniProt: P51648

  • Chr Location
    17p11.2; chr17:19648136-19685760 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ALDH3A2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit impaired long-chain base metabolism, hyperproliferation of keratinocytes, widened intercellular spaces in the basal layer of the epidermis, and delayed barrier recovery after stratum corneum perturbation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    104
  • cDNA Data
    114
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11671 NCBI Gene Model | MGI Sequence Detail 44028 C57BL/6J ±  kb
    transcript NM_001331114 RefSeq | MGI Sequence Detail 3246 ZRU/MplStud  
    polypeptide P47740 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 116
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1207, MGD-MRK-1208, MGD-MRK-1214, MGD-MRK-1215, MGD-MRK-16379, MGD-MRK-16380, MGI:2144079, MGI:99597, MGI:99598
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 7
      Diseases 3
      Gene Ontology 10
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory