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Fkbp3 Gene Detail
Summary
  • Symbol
    Fkbp3
  • Name
    FK506 binding protein 3
  • Synonyms
    25kDa, FKBP25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353460
    NCBI Gene: 30795
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:65109206-65120712 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 27.21 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    380 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353460
 protein coding gene Chr12:65109198-65120781 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019779
 protein coding gene Chr12:64541791-64557581 (-)
A/J MGP_AJ_G0019738
 protein coding gene Chr12:62160472-62172166 (-)
AKR/J MGP_AKRJ_G0019713
 protein coding gene Chr12:64139830-64151357 (-)
BALB/cJ MGP_BALBcJ_G0019718
 protein coding gene Chr12:62601888-62613474 (-)
C3H/HeJ MGP_C3HHeJ_G0019523
 protein coding gene Chr12:64485935-64497425 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020170
 protein coding gene Chr12:66579015-66595045 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017790
 protein coding gene Chr12:59976842-59988212 (-)
CAST/EiJ MGP_CASTEiJ_G0019075
 protein coding gene Chr12:59192640-59204152 (-)
CBA/J MGP_CBAJ_G0019492
 protein coding gene Chr12:69005235-69016827 (-)
DBA/2J MGP_DBA2J_G0019608
 protein coding gene Chr12:62088578-62100005 (-)
FVB/NJ MGP_FVBNJ_G0019596
 protein coding gene Chr12:61115050-61126225 (-)
LP/J MGP_LPJ_G0019680
 protein coding gene Chr12:64563170-64575833 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019634
 protein coding gene Chr12:71872339-71883793 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020204
 protein coding gene Chr12:63527185-63538638 (-)
PWK/PhJ MGP_PWKPhJ_G0018841
 protein coding gene Chr12:56355213-56373639 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018635
 protein coding gene Chr12:57850048-57861605 (-)
WSB/EiJ MGP_WSBEiJ_G0019126
 protein coding gene Chr12:64058665-64070143 (-)



Homology
more
  • Human Ortholog
    FKBP3, FKBP prolyl isomerase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FKBP3, FKBP prolyl isomerase 3
  • Synonyms
    FKBP-25, FKBP25, FKBP-3, PPIase
  • Links
    NCBI Gene ID: 2287
    neXtProt AC: NX_Q00688
    UniProt: Q00688

  • Chr Location
    14q21.2; chr14:45115599-45135319 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    33
  • Targeted
    2
  • Genomic Mutations
    1 involving Fkbp3
  • Find Mice (IMSR)
    30 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    140
  • cDNA Data
    119
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 30795 NCBI Gene Model | MGI Sequence Detail 11507 C57BL/6J ±  kb
transcript NM_013902 RefSeq | MGI Sequence Detail 945 C57BL/6  
polypeptide Q62446 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000007539 peptidyl-prolyl cis-trans isomerase FKBP3
    (term hierarchy)
  • PDB
    3KZ7
  • EC
    5.2.1.8
  • InterPro Domains
    IPR041200 FKBP3, basic tilted helix bundle domain
    IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
    IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
    IPR043368 Peptidyl-prolyl cis-trans isomerase FKBP3
  • GlyGen
    Q62446 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 123
    cDNA 119
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 49
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:62503 Murphy M, et al., Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev. 1996 Dec 1;10(23):2971-80
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory