Slc25a10 MGI Mouse Gene Detail - MGI:1353497 - solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10

Symbol

Slc25a10
Name

solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms

Dic

Feature Type

protein coding gene
IDs

MGI:1353497
NCBI Gene: 27376
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:120382666-120390013 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 84.19 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

277 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353497	protein coding gene	Chr11:120382663-120391987 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019506	protein coding gene	Chr11:124961021-124968369 (+)
A/J	MGP_AJ_G0019474	protein coding gene	Chr11:119400180-119407528 (+)
AKR/J	MGP_AKRJ_G0019444	protein coding gene	Chr11:122992986-123000334 (+)
BALB/cJ	MGP_BALBcJ_G0019449	protein coding gene	Chr11:119755799-119763149 (+)
C3H/HeJ	MGP_C3HHeJ_G0019255	protein coding gene	Chr11:123328625-123335975 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019897	protein coding gene	Chr11:128738486-128745834 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017523	protein coding gene	Chr11:116388204-116395448 (+)
CAST/EiJ	MGP_CASTEiJ_G0018809	protein coding gene	Chr11:124817961-124825303 (+)
CBA/J	MGP_CBAJ_G0019226	protein coding gene	Chr11:133778296-133785646 (+)
DBA/2J	MGP_DBA2J_G0019338	protein coding gene	Chr11:118769084-118776434 (+)
FVB/NJ	MGP_FVBNJ_G0019330	protein coding gene	Chr11:118479255-118486603 (+)
LP/J	MGP_LPJ_G0019410	protein coding gene	Chr11:125262447-125269795 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019363	protein coding gene	Chr11:132620301-132627649 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019937	protein coding gene	Chr11:123678759-123686109 (+)
PWK/PhJ	MGP_PWKPhJ_G0018575	protein coding gene	Chr11:120202671-120209992 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018367	protein coding gene	Chr11:123440469-123447809 (+)
WSB/EiJ	MGP_WSBEiJ_G0018861	protein coding gene	Chr11:123670190-123677520 (+)

Human Ortholog

SLC25A10, solute carrier family 25 member 10

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A10, solute carrier family 25 member 10
Synonyms

DIC, MTDPS19
Links

HGNC:10980

NCBI Gene ID: 1468

neXtProt AC: NX_Q9UBX3

UniProt: Q9UBX3
Chr Location

17q25.3; chr17:81712236-81721016 (+) GRCh38

MGI Vertebrate Homology

Slc25a10 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC25A10
Gene Tree

Slc25a10

Diseases

1 with human SLC25A10 associations

				Human Disease	Mouse Models
				mitochondrial DNA depletion syndrome 19 IDs mitochondrial DNA depletion syndrome 19 DOID:0070450 OMIM:618972

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

49
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

5
cDNA Data

162
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a10

ZFIN slc25a10b

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All Sequences

43
RefSeq

2
UniProt

1
CCDS

CCDS25738.1

Ensembl

ENSMUSG00000025792 (Evidence)
NCBI Gene

27376

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025792	Ensembl Gene Model \| MGI Sequence Detail	7348	C57BL/6J	± kb
transcript	ENSMUST00000026899	Ensembl \| MGI Sequence Detail	2023	Not Applicable
polypeptide	ENSMUSP00000026899	Ensembl \| MGI Sequence Detail	287	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015005 mitochondrial dicarboxylate carrier

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR002067 Mitochondrial carrier protein

IPR050391 Mitochondrial Metabolite Transporter

IPR018108 Mitochondrial substrate/solute carrier
GlyGen

Q9QZD8 1 site, 1 O-linked glycan (1 site)

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All nucleic 165

cDNA 163

Primer pair 2

Microarray probesets 4

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MGI:1351621

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 13

Phenotypes 8
Earliest

J:320601 Fiermonte G, et al., The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. J Biol Chem. 1998 Sep 18;273(38):24754-9
Latest

J:349093 Dearden L, et al., Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. PLoS Biol. 2024 Jun;22(6):e3002641

TSS for Slc25a10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106298	Chr11:120382692-120382715 (+)	38 bp
Tssr106299	Chr11:120382721-120382747 (+)	68 bp
Tssr106300	Chr11:120382755-120382775 (+)	99 bp
Tssr106301	Chr11:120382788-120382797 (+)	127 bp
Tssr106302	Chr11:120388911-120388929 (+)	6,254 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24