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Vapa Gene Detail
Summary
  • Symbol
    Vapa
  • Name
    vesicle-associated membrane protein, associated protein A
  • Synonyms
    synaptobrevin-associated protein of 33kDa, VAP33
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353561
    NCBI Gene: 30960
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:65885322-65920550 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 34.90 cM, cytoband E1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    788 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353561
 protein coding gene Chr17:65885322-65925441 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023977
 protein coding gene Chr17:67708332-67743061 (-)
A/J MGP_AJ_G0023935
 protein coding gene Chr17:65692619-65726250 (-)
AKR/J MGP_AKRJ_G0023904
 protein coding gene Chr17:66605224-66638738 (-)
BALB/cJ MGP_BALBcJ_G0023936
 protein coding gene Chr17:65626496-65659959 (-)
C3H/HeJ MGP_C3HHeJ_G0023700
 protein coding gene Chr17:67494795-67528328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024382
 protein coding gene Chr17:70339150-70374010 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021828
 protein coding gene Chr17:61723252-61756195 (-)
CAST/EiJ MGP_CASTEiJ_G0023182
 protein coding gene Chr17:67831040-67865459 (-)
CBA/J MGP_CBAJ_G0023676
 protein coding gene Chr17:73085476-73118971 (-)
DBA/2J MGP_DBA2J_G0023804
 protein coding gene Chr17:64437456-64470843 (-)
FVB/NJ MGP_FVBNJ_G0023770
 protein coding gene Chr17:63926079-63959881 (-)
LP/J MGP_LPJ_G0023886
 protein coding gene Chr17:68435575-68470617 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023798
 protein coding gene Chr17:73192872-73226395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024426
 protein coding gene Chr17:67072981-67106497 (-)
PWK/PhJ MGP_PWKPhJ_G0022928
 protein coding gene Chr17:63703351-63737525 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022739
 protein coding gene Chr17:63741306-63776231 (-)
WSB/EiJ MGP_WSBEiJ_G0023248
 protein coding gene Chr17:67769067-67804938 (-)



Homology
more
  • Human Ortholog
    VAPA, VAMP associated protein A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VAPA, VAMP associated protein A
  • Synonyms
    hVAP-33, VAMP-A, VAP-33, VAP33, VAP-A
  • Links
    NCBI Gene ID: 9218
    neXtProt AC: NX_Q9P0L0
    UniProt: Q9P0L0

  • Chr Location
    18p11.22; chr18:9914016-9960021 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    1
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024091 Ensembl Gene Model | MGI Sequence Detail 35229 C57BL/6J ±  kb
transcript ENSMUST00000024897 Ensembl | MGI Sequence Detail 3369 Not Applicable  
polypeptide ENSMUSP00000024897 Ensembl | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017257 vesicle-associated membrane protein-associated protein A
    (term hierarchy)
  • PDB
    2CRI
  • InterPro Domains
    IPR013783 Immunoglobulin-like fold
    IPR000535 Major sperm protein (MSP) domain
    IPR008962 PapD-like superfamily
    IPR016763 Vesicle-associated membrane-protein-associated protein
  • GlyGen
    Q9WV55 3 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 6
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:60136 Skehel PA, et al., Mouse VAP33 is associated with the endoplasmic reticulum and microtubules. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1101-6
  • Latest
    J:297547 Leca I, et al., A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse. PLoS Genet. 2020 Nov;16(11):e1009104
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory