Cbx8 MGI Mouse Gene Detail - MGI:1353589

Symbol

Cbx8
Name

chromobox 8
Synonyms

Pc3, polycomb 3

Feature Type

protein coding gene
IDs

MGI:1353589
NCBI Gene: 30951
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:118929262-118931739 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 83.33 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

88 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353589	protein coding gene	Chr11:118927131-118931795 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019473	protein coding gene	Chr11:123381385-123387610 (-)
A/J	MGP_AJ_G0019441	protein coding gene	Chr11:117932544-117937208 (-)
AKR/J	MGP_AKRJ_G0019411	protein coding gene	Chr11:121490405-121495069 (-)
BALB/cJ	MGP_BALBcJ_G0019416	protein coding gene	Chr11:118291725-118296391 (-)
C3H/HeJ	MGP_C3HHeJ_G0019222	protein coding gene	Chr11:121803275-121807972 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019865	protein coding gene	Chr11:127149302-127154923 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017490	protein coding gene	Chr11:114927870-114932548 (-)
CAST/EiJ	MGP_CASTEiJ_G0018776	protein coding gene	Chr11:123249365-123255466 (-)
CBA/J	MGP_CBAJ_G0019193	protein coding gene	Chr11:132085598-132093020 (-)
DBA/2J	MGP_DBA2J_G0019305	protein coding gene	Chr11:117308818-117313489 (-)
FVB/NJ	MGP_FVBNJ_G0019297	protein coding gene	Chr11:116966727-116972392 (-)
LP/J	MGP_LPJ_G0019375	protein coding gene	Chr11:123706907-123711588 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019330	protein coding gene	Chr11:131052986-131058898 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019904	protein coding gene	Chr11:122159297-122163970 (-)
PWK/PhJ	MGP_PWKPhJ_G0018542	protein coding gene	Chr11:118706884-118709988 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018334	protein coding gene	Chr11:121902548-121907193 (-)
WSB/EiJ	MGP_WSBEiJ_G0018828	protein coding gene	Chr11:122127693-122132349 (-)

Human Ortholog

CBX8, chromobox 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CBX8, chromobox 8
Synonyms

PC3, RC1
Links

HGNC:15962

NCBI Gene ID: 57332

neXtProt AC: NX_Q9HC52

UniProt: Q9HC52
Chr Location

17q25.3; chr17:79792132-79801683 (-) GRCh38

MGI Vertebrate Homology

Cbx8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CBX8
Gene Tree

Cbx8

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired MLL-AF9 transformation but are otherwise viable with normal hematopoiesis.

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All GO Annotations

36
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

818
Tissues

111
cDNA Data

26
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CBX8

Xenbase cbx8

ZFIN cbx8a, cbx8b

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS25709.1

Ensembl

ENSMUSG00000025578 (Evidence)
NCBI Gene

30951

			Length	Strain/Species	Flank
genomic	30951	NCBI Gene Model \| MGI Sequence Detail	2478	C57BL/6J	± kb
transcript	NM_013926	RefSeq \| MGI Sequence Detail	1413	Not Specified
polypeptide	Q9QXV1	UniProt \| EBI \| MGI Sequence Detail	362	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005089 chromobox protein homolog 8

(term hierarchy)
PDB

2DNV
InterPro Domains

IPR033773 CBX family C-terminal motif

IPR000953 Chromo/chromo shadow domain

IPR023780 Chromo domain

IPR023779 Chromo domain, conserved site

IPR016197 Chromo-like domain superfamily

IPR052458 Polycomb group PRC1-like complex component

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All nucleic 28

Genomic 1

cDNA 27

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 6
Earliest

J:60239 Hemenway CS, et al., Identification and analysis of a third mouse Polycomb gene, MPc3. Gene. 2000 Jan 25;242(1-2):31-40
Latest

J:338403 Cho KW, et al., Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis. Circulation. 2023 Jun 13;147(24):1823-1842

TSS for Cbx8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112203	Chr11:118931731-118931763 (-)	-8 bp
Tssr112202	Chr11:118931709-118931729 (-)	20 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24