Siva1 MGI Mouse Gene Detail - MGI:1353606 - SIVA1, apoptosis-inducing factor

Symbol

Siva1
Name

SIVA1, apoptosis-inducing factor
Synonyms

CD27bp

Feature Type

protein coding gene
IDs

MGI:1353606
NCBI Gene: 30954
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:112611262-112615586 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.20 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

253 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353606	protein coding gene	Chr12:112611113-112615586 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020155	protein coding gene	Chr12:115105623-115109947 (+)
A/J	MGP_AJ_G0020111	protein coding gene	Chr12:110674765-110679097 (+)
AKR/J	MGP_AKRJ_G0020086	protein coding gene	Chr12:113863944-113868275 (+)
BALB/cJ	MGP_BALBcJ_G0020096	protein coding gene	Chr12:111118090-111122414 (+)
C3H/HeJ	MGP_C3HHeJ_G0019898	protein coding gene	Chr12:114373637-114377968 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020541	protein coding gene	Chr12:118672153-118676477 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018154	protein coding gene	Chr12:107105254-107109563 (+)
CAST/EiJ	MGP_CASTEiJ_G0019438	protein coding gene	Chr12:109217658-109224518 (+)
CBA/J	MGP_CBAJ_G0019865	protein coding gene	Chr12:123208376-123212707 (+)
DBA/2J	MGP_DBA2J_G0019982	protein coding gene	Chr12:110152838-110157162 (+)
FVB/NJ	MGP_FVBNJ_G0019967	protein coding gene	Chr12:108979492-108983832 (+)
LP/J	MGP_LPJ_G0020056	protein coding gene	Chr12:114932338-114936662 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020005	protein coding gene	Chr12:126289070-126293394 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020570	protein coding gene	Chr12:113386531-113390877 (+)
PWK/PhJ	MGP_PWKPhJ_G0019200	protein coding gene	Chr12:104810548-104815044 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019003	protein coding gene	Chr12:107550219-107554575 (+)
WSB/EiJ	MGP_WSBEiJ_G0019498	protein coding gene	Chr12:114295941-114300275 (+)

Human Ortholog

SIVA1, SIVA1 apoptosis inducing factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIVA1, SIVA1 apoptosis inducing factor
Synonyms

CD27BP, SIVA, Siva-1, Siva-2
Links

HGNC:17712

NCBI Gene ID: 10572

neXtProt AC: NX_O15304

UniProt: O15304
Chr Location

14q32.33; chr14:104753147-104768494 (+) GRCh38

MGI Vertebrate Homology

Siva1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SIVA1
Protein SuperFamily

Siva_cd27_bd
Gene Tree

Siva1

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Phenotype Summary

4 phenotypes from 3 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

1
Gene trapped

11
Targeted

4
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

15
cDNA Data

65
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase siva1

ZFIN siva1

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All Sequences

53
RefSeq

4
UniProt

2
CCDS

CCDS26193.1, CCDS49189.1

Ensembl

ENSMUSG00000064326 (Evidence)
NCBI Gene

30954

			Length	Strain/Species	Flank
genomic	30954	NCBI Gene Model \| MGI Sequence Detail	4325	C57BL/6J	± kb
transcript	NM_013929	RefSeq \| MGI Sequence Detail	782	C57BL/6
polypeptide	O54926	UniProt \| EBI \| MGI Sequence Detail	175	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014895 apoptosis regulatory protein Siva

(term hierarchy)
InterPro Domains

IPR022773 Siva

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All nucleic 65

cDNA 65

Microarray probesets 6

Summaries

All 54

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 12
Earliest

J:117434 Prasad KV, et al., CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6346-51
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Siva1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115387	Chr12:112611070-112611118 (+)	-168 bp
Tssr115388	Chr12:112611275-112611289 (+)	20 bp
Tssr115389	Chr12:112611296-112611315 (+)	44 bp
Tssr115390	Chr12:112611326-112611396 (+)	99 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24