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Gnl3 Gene Detail
Summary
  • Symbol
    Gnl3
  • Name
    guanine nucleotide binding protein nucleolar 3
  • Synonyms
    NS, nucleostemin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353651
    NCBI Gene: 30877
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30734390-30741088 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353651
 protein coding gene Chr14:30734390-30741109 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021116
 protein coding gene Chr14:24177372-24185680 (-)
A/J MGP_AJ_G0021064
 protein coding gene Chr14:23266588-23273243 (-)
AKR/J MGP_AKRJ_G0021041
 protein coding gene Chr14:24389832-24396487 (-)
BALB/cJ MGP_BALBcJ_G0021068
 protein coding gene Chr14:23373347-23380419 (-)
C3H/HeJ MGP_C3HHeJ_G0020851
 protein coding gene Chr14:24248251-24254906 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021500
 protein coding gene Chr14:25139585-25146240 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019063
 protein coding gene Chr14:23326269-23332357 (-)
CAST/EiJ MGP_CASTEiJ_G0020376
 protein coding gene Chr14:24017985-24024623 (-)
CBA/J MGP_CBAJ_G0020818
 protein coding gene Chr14:26109730-26116385 (-)
DBA/2J MGP_DBA2J_G0020940
 protein coding gene Chr14:23292193-23298849 (-)
FVB/NJ MGP_FVBNJ_G0020924
 protein coding gene Chr14:23252010-23258665 (-)
LP/J MGP_LPJ_G0021009
 protein coding gene Chr14:24502014-24508670 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020950
 protein coding gene Chr14:25376227-25384111 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021533
 protein coding gene Chr14:24146193-24152848 (-)
PWK/PhJ MGP_PWKPhJ_G0020124
 protein coding gene Chr14:22746593-22753218 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019948
 protein coding gene Chr14:23736244-23742707 (-)
WSB/EiJ MGP_WSBEiJ_G0020431
 protein coding gene Chr14:24206098-24212753 (-)



Homology
more
  • Human Ortholog
    GNL3, G protein nucleolar 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNL3, G protein nucleolar 3
  • Synonyms
    C77032, E2IG3, NNP47, NS, Nug1
  • Links
    NCBI Gene ID: 26354
    neXtProt AC: NX_Q9BVP2
    UniProt: Q9BVP2

  • Chr Location
    3p21.1; chr3:52681156-52694497 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    4 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene leads to early embryonic loss as blastocysts fail to enter the S phase. MEFs heterozygous for a gene trap allele have reduced proliferative capacity while MEFs heterozygous for a null allele show reduced doubling rates,increased apoptosis and premature senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    32
  • cDNA Data
    135
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30877 NCBI Gene Model | MGI Sequence Detail 6699 C57BL/6J ±  kb
    transcript NM_153547 RefSeq | MGI Sequence Detail 1935 ZRU/MplStud  
    polypeptide Q8CI11 UniProt | EBI | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008117 guanine nucleotide-binding protein-like 3
      (term hierarchy)
    • InterPro Domains
      IPR030378 Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
      IPR006073 GTP binding domain
      IPR023179 GTP-binding protein, orthogonal bundle domain superfamily
      IPR014813 Guanine nucleotide-binding protein-like 3, N-terminal domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR050755 TRAFAC YlqF/YawG GTPases, Ribosome Maturation
    • GlyGen
      Q8CI11 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 136
      cDNA 135
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2387185
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory