Usp25 MGI Mouse Gene Detail - MGI:1353655 - ubiquitin specific peptidase 25

Symbol

Usp25
Name

ubiquitin specific peptidase 25

Feature Type

protein coding gene
IDs

MGI:1353655
NCBI Gene: 30940
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr16:76810594-76913668 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 44.40 cM, cytoband C3.1
Mapping Data

3 experiments

SNPs within 2kb

3276 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353655	protein coding gene	Chr16:76810573-76913671 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022957	protein coding gene	Chr16:77119010-77227067 (+)
A/J	MGP_AJ_G0022925	protein coding gene	Chr16:73719001-73824492 (+)
AKR/J	MGP_AKRJ_G0022895	protein coding gene	Chr16:75939906-76046265 (+)
BALB/cJ	MGP_BALBcJ_G0022927	protein coding gene	Chr16:74097100-74201117 (+)
C3H/HeJ	MGP_C3HHeJ_G0022689	protein coding gene	Chr16:76399446-76505013 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023375	protein coding gene	Chr16:79595798-79708844 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020878	protein coding gene	Chr16:72192616-72300870 (+)
CAST/EiJ	MGP_CASTEiJ_G0022212	protein coding gene	Chr16:76771462-76904289 (+)
CBA/J	MGP_CBAJ_G0022659	protein coding gene	Chr16:83005814-83126918 (+)
DBA/2J	MGP_DBA2J_G0022792	protein coding gene	Chr16:73552307-73659629 (+)
FVB/NJ	MGP_FVBNJ_G0022767	protein coding gene	Chr16:72918225-73025368 (+)
LP/J	MGP_LPJ_G0022862	protein coding gene	Chr16:76872858-76985347 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022786	protein coding gene	Chr16:86086497-86208813 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023393	protein coding gene	Chr16:76272275-76377165 (+)
PWK/PhJ	MGP_PWKPhJ_G0021954	protein coding gene	Chr16:73746975-73877862 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021784	protein coding gene	Chr16:75872390-76007341 (+)
WSB/EiJ	MGP_WSBEiJ_G0022259	protein coding gene	Chr16:76467777-76575861 (+)

Human Ortholog

USP25, ubiquitin specific peptidase 25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP25, ubiquitin specific peptidase 25
Synonyms

USP21
Links

HGNC:12624

NCBI Gene ID: 29761

neXtProt AC: NX_Q9UHP3

UniProt: Q9UHP3
Chr Location

21q21.1; chr21:15729982-15880064 (+) GRCh38

MGI Vertebrate Homology

Usp25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP25
Gene Tree

Usp25

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

6
Gene trapped

5
Targeted

10
Genomic Mutations

5 involving Usp25
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

75 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis.

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All GO Annotations

34
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

952
Tissues

84
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp25

ZFIN usp25

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All Sequences

59
RefSeq

8
UniProt

6
CCDS

CCDS28275.1

Ensembl

ENSMUSG00000022867 (Evidence)
NCBI Gene

30940

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022867	Ensembl Gene Model \| MGI Sequence Detail	103075	C57BL/6J	± kb
transcript	ENSMUST00000239066	Ensembl \| MGI Sequence Detail	4986	Not Applicable
polypeptide	ENSMUSP00000159060	Ensembl \| MGI Sequence Detail	1125	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017163 ubiquitin carboxyl-terminal hydrolase 25

(term hierarchy)
PDB

1VDL
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR009060 UBA-like superfamily

IPR044635 Ubiquitin carboxyl-terminal hydrolase 14-like

IPR050164 Ubiquitin carboxyl-terminal hydrolases

IPR003903 Ubiquitin interacting motif

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain
GlyGen

P57080 1 site, 1 N-linked glycan (1 site)

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All nucleic 19

cDNA 15

Primer pair 3

Other 1

Microarray probesets 5

Summaries

All 72

Developmental Gene Expression 6

Diseases 1

Gene Ontology 7

Phenotypes 31
Earliest

J:60249 Valero R, et al., USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Usp25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139026	Chr16:76810588-76810663 (+)	32 bp
Tssr139027	Chr16:76810665-76810676 (+)	77 bp
Tssr139028	Chr16:76810698-76810705 (+)	108 bp
Tssr139029	Chr16:76823485-76823516 (+)	12,907 bp
Tssr139030	Chr16:76834284-76834302 (+)	23,699 bp
Tssr139031	Chr16:76868576-76868596 (+)	57,992 bp
Tssr139032	Chr16:76868627-76868644 (+)	58,042 bp
Tssr139033	Chr16:76871739-76871761 (+)	61,156 bp
Tssr139034	Chr16:76874009-76874020 (+)	63,421 bp
Tssr139035	Chr16:76874067-76874085 (+)	63,482 bp
Tssr139036	Chr16:76882363-76882367 (+)	71,771 bp
Tssr139037	Chr16:76890502-76890516 (+)	79,915 bp
Tssr139038	Chr16:76908510-76908524 (+)	97,923 bp
Tssr139039	Chr16:76912506-76912519 (+)	101,919 bp
Tssr139040	Chr16:76912773-76912787 (+)	102,186 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24