Cbarp MGI Mouse Gene Detail - MGI:1354170 - calcium channel, voltage-dependent, beta subunit associated regulatory protein

Symbol

Cbarp
Name

calcium channel, voltage-dependent, beta subunit associated regulatory protein
Synonyms

Dos, R29144/1

Feature Type

protein coding gene
IDs

MGI:1354170
NCBI Gene: 100503659
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:79966268-79976189 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

161 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354170	protein coding gene	Chr10:79966268-79976669 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017483	protein coding gene	Chr10:80715640-80725977 (-)
A/J	MGP_AJ_G0017461	protein coding gene	Chr10:77892145-77902488 (-)
AKR/J	MGP_AKRJ_G0017422	protein coding gene	Chr10:80018195-80030780 (-)
BALB/cJ	MGP_BALBcJ_G0017423	protein coding gene	Chr10:78115807-78126135 (-)
C3H/HeJ	MGP_C3HHeJ_G0017246	protein coding gene	Chr10:80119066-80129432 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017877	protein coding gene	Chr10:83498262-83508681 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015565	protein coding gene	Chr10:74117164-74127530 (-)
CAST/EiJ	MGP_CASTEiJ_G0016813	protein coding gene	Chr10:80316595-80329951 (-)
CBA/J	MGP_CBAJ_G0017218	protein coding gene	Chr10:86737554-86747951 (-)
DBA/2J	MGP_DBA2J_G0017324	protein coding gene	Chr10:77107111-77120479 (-)
FVB/NJ	MGP_FVBNJ_G0017318	protein coding gene	Chr10:76291078-76304747 (-)
LP/J	MGP_LPJ_G0017395	protein coding gene	Chr10:81190963-81204149 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017344	protein coding gene	Chr10:88688271-88698601 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017918	protein coding gene	Chr10:79998641-80011285 (-)
PWK/PhJ	MGP_PWKPhJ_G0016594	protein coding gene	Chr10:76976679-76987550 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016383	protein coding gene	Chr10:78981956-78992334 (-)
WSB/EiJ	MGP_WSBEiJ_G0016873	protein coding gene	Chr10:80029522-80045082 (-)

Human Ortholog

CBARP, CACN subunit beta associated regulatory protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CBARP, CACN subunit beta associated regulatory protein
Synonyms

BARP, C19orf26, DOS
Links

HGNC:28617

NCBI Gene ID: 255057

neXtProt AC: NX_Q8N350

UniProt: Q8N350
Chr Location

19p13.3; chr19:1228287-1238502 (-) GRCh38

MGI Vertebrate Homology

Cbarp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CBARP
Gene Tree

Cbarp

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Phenotype Summary

25 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Cbarp
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show alterations in presynaptic striatal nicotinic acetylcholine receptors and reduced persistent nicotine-induced dopamine release in striatal synaptosomes. Homozygous KO also leads to lower body weight, reduced grip strength, hypoactivity, increased sociability, decreased startle reflex and enhanced spatial working memory.

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

816
Tissues

11
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cbarp

ZFIN cbarpb

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All Sequences

94
RefSeq

33
UniProt

4
CCDS

CCDS56734.1

Ensembl

ENSMUSG00000035640 (Evidence)
NCBI Gene

100503659

			Length	Strain/Species	Flank
genomic	100503659	NCBI Gene Model \| MGI Sequence Detail	9922	C57BL/6J	± kb
transcript	NM_001421397	RefSeq \| MGI Sequence Detail	3328	C57BL/6
polypeptide	Q66L44	UniProt \| EBI \| MGI Sequence Detail	698	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006641 voltage-dependent calcium channel beta subunit-associated regulatory protein

(term hierarchy)
InterPro Domains

IPR037658 Voltage-dependent calcium channel beta subunit-associated regulatory protein
GlyGen

Q66L44 1 site

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All nucleic 12

Genomic 1

cDNA 11

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cbarp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98411	Chr10:79977196-79977216 (-)	-1,017 bp
Tssr98410	Chr10:79977144-79977156 (-)	-961 bp
Tssr98409	Chr10:79975181-79975204 (-)	996 bp
Tssr98408	Chr10:79975023-79975038 (-)	1,158 bp
Tssr98407	Chr10:79974993-79975006 (-)	1,189 bp
Tssr98406	Chr10:79973210-79973277 (-)	2,945 bp
Tssr98405	Chr10:79972985-79973018 (-)	3,187 bp
Tssr98404	Chr10:79972305-79972318 (-)	3,877 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24