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Sall2 Gene Detail
Summary
  • Symbol
    Sall2
  • Name
    spalt like transcription factor 2
  • Synonyms
    mKIAA0360, Msal-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354373
    NCBI Gene: 50524
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52548634-52566127 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.89 cM, cytoband B-C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354373
 protein coding gene Chr14:52548629-52566219 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021297
 protein coding gene Chr14:46352491-46371908 (-)
A/J MGP_AJ_G0021254
 protein coding gene Chr14:45128018-45145461 (-)
AKR/J MGP_AKRJ_G0021230
 protein coding gene Chr14:46764919-46782396 (-)
BALB/cJ MGP_BALBcJ_G0021258
 protein coding gene Chr14:45241178-45258819 (-)
C3H/HeJ MGP_C3HHeJ_G0021038
 protein coding gene Chr14:46565182-46584217 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021697
 protein coding gene Chr14:48409150-48428900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019241
 protein coding gene Chr14:44334323-44351896 (-)
CAST/EiJ MGP_CASTEiJ_G0020557
 protein coding gene Chr14:43543904-43561491 (-)
CBA/J MGP_CBAJ_G0021005
 protein coding gene Chr14:49859536-49881290 (-)
DBA/2J MGP_DBA2J_G0021126
 protein coding gene Chr14:44903727-44925189 (-)
FVB/NJ MGP_FVBNJ_G0021109
 protein coding gene Chr14:44489582-44508414 (-)
LP/J MGP_LPJ_G0021201
 protein coding gene Chr14:46947824-46967369 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021132
 protein coding gene Chr14:49307312-49327058 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021724
 protein coding gene Chr14:46141659-46161487 (-)
PWK/PhJ MGP_PWKPhJ_G0020306
 protein coding gene Chr14:41644772-41663429 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020133
 protein coding gene Chr14:42182798-42200483 (-)
WSB/EiJ MGP_WSBEiJ_G0020610
 protein coding gene Chr14:46472544-46489905 (-)



Homology
more
  • Human Ortholog
    SALL2, spalt like transcription factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SALL2, spalt like transcription factor 2
  • Synonyms
    COLB, HSAL2, p150(Sal2), Sal-2, ZNF795
  • Links
    NCBI Gene ID: 6297
    neXtProt AC: NX_Q9Y467
    UniProt: Q9Y467

  • Chr Location
    14q11.2; chr14:21521080-21537216 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SALL2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 6 genetic backgrounds
    14 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in no apparent abnormal phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    900
  • Tissues
    131
  • cDNA Data
    15
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50524 NCBI Gene Model | MGI Sequence Detail 17494 C57BL/6J ±  kb
    transcript NM_015772 RefSeq | MGI Sequence Detail 5058 C57BL/6  
    polypeptide Q9QX96 UniProt | EBI | MGI Sequence Detail 1004 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 17
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145603, MGI:2145841
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 17
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:59254 Kohlhase J, et al., Genomic cloning, chromosomal mapping, and expression analysis of msal-2. Mamm Genome. 2000 Jan;11(1):64-8
    • Latest
      J:354846 Xiong H, et al., SALL2 regulates neural differentiation of mouse embryonic stem cells through Tuba1a. Cell Death Dis. 2024 Sep 30;15(9):710
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory