Ero1a MGI Mouse Gene Detail - MGI:1354385 - endoplasmic reticulum oxidoreductase 1 alpha

Symbol

Ero1a
Name

endoplasmic reticulum oxidoreductase 1 alpha
Synonyms

Ero1l

Feature Type

protein coding gene
IDs

MGI:1354385
NCBI Gene: 50527
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr14:45520544-45556029 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 22.86 cM, cytoband C-D
Mapping Data

1 experiment

SNPs within 2kb

956 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354385	protein coding gene	Chr14:45520544-45556228 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021206	protein coding gene	Chr14:38901183-38939913 (-)
A/J	MGP_AJ_G0021152	protein coding gene	Chr14:37746417-37783430 (-)
AKR/J	MGP_AKRJ_G0021130	protein coding gene	Chr14:39228690-39266998 (-)
BALB/cJ	MGP_BALBcJ_G0021156	protein coding gene	Chr14:37798807-37833780 (-)
C3H/HeJ	MGP_C3HHeJ_G0020939	protein coding gene	Chr14:39036536-39074524 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021590	protein coding gene	Chr14:40598465-40634175 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019149	protein coding gene	Chr14:37171010-37211556 (-)
CAST/EiJ	MGP_CASTEiJ_G0020464	protein coding gene	Chr14:36148693-36191686 (-)
CBA/J	MGP_CBAJ_G0020905	protein coding gene	Chr14:41881160-41928418 (-)
DBA/2J	MGP_DBA2J_G0021028	protein coding gene	Chr14:37668869-37705934 (-)
FVB/NJ	MGP_FVBNJ_G0021012	protein coding gene	Chr14:37428046-37463361 (-)
LP/J	MGP_LPJ_G0021098	protein coding gene	Chr14:39186704-39227444 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021038	protein coding gene	Chr14:41290180-41329431 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021623	protein coding gene	Chr14:38767028-38804294 (-)
PWK/PhJ	MGP_PWKPhJ_G0020213	protein coding gene	Chr14:34530481-34566669 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020035	protein coding gene	Chr14:34921583-34960609 (-)
WSB/EiJ	MGP_WSBEiJ_G0020520	protein coding gene	Chr14:38874235-38915440 (-)

Human Ortholog

ERO1A, endoplasmic reticulum oxidoreductase 1 alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERO1A, endoplasmic reticulum oxidoreductase 1 alpha
Synonyms

ERO1-alpha, Ero1alpha, ERO1-L, ERO1L, ERO1LA, ERO1-L-alpha
Links

HGNC:13280

NCBI Gene ID: 30001

neXtProt AC: NX_Q96HE7

UniProt: Q96HE7
Chr Location

14q22.1; chr14:52639915-52695900 (-) GRCh38

MGI Vertebrate Homology

Ero1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ERO1A
Protein SuperFamily

ERO1
Gene Tree

Ero1a

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Targeted

2
Genomic Mutations

1 involving Ero1a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

Mice homozygous for a gene trapped allele exhibit decreased apoptosis and calcium release in macrophages exposed to endoplasmic reticulum stress.

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All GO Annotations

45
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

196
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ero1a

ZFIN ero1a

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All Sequences

51
RefSeq

2
UniProt

6
CCDS

CCDS36893.1

Ensembl

ENSMUSG00000021831 (Evidence)
NCBI Gene

50527

			Length	Strain/Species	Flank
genomic	50527	NCBI Gene Model \| MGI Sequence Detail	35486	C57BL/6J	± kb
transcript	NM_015774	RefSeq \| MGI Sequence Detail	4435	C57BL/6
polypeptide	Q8R180	UniProt \| EBI \| MGI Sequence Detail	464	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007187 ERO1-like protein alpha

(term hierarchy)
EC

1.8.4.-
InterPro Domains

IPR007266 Endoplasmic reticulum oxidoreductin 1

IPR037192 ERO1-like superfamily
GlyGen

Q8R180 2 sites, 5 N-linked glycans (2 sites)

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All nucleic 198

cDNA 197

Primer pair 1

Microarray probesets 6

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MGI:6390571

Summaries

All 60

Developmental Gene Expression 6

Gene Ontology 16

Phenotypes 18
Earliest

J:60564 Cabibbo A, et al., ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem. 2000 Feb 18;275(7):4827-33
Latest

J:356241 Germani S, et al., SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA. Cell Rep Med. 2024 Mar 19;5(3):101439

TSS for Ero1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128250	Chr14:45556184-45556227 (-)	-177 bp
Tssr128249	Chr14:45556013-45556036 (-)	4 bp
Tssr128248	Chr14:45555987-45556003 (-)	34 bp
Tssr128247	Chr14:45555966-45555977 (-)	57 bp
Tssr128246	Chr14:45552246-45552252 (-)	3,780 bp
Tssr128245	Chr14:45550813-45550850 (-)	5,197 bp
Tssr128244	Chr14:45543668-45543673 (-)	12,358 bp
Tssr128243	Chr14:45537413-45537426 (-)	18,609 bp
Tssr128242	Chr14:45533420-45533433 (-)	22,602 bp
Tssr128241	Chr14:45533336-45533372 (-)	22,675 bp
Tssr128240	Chr14:45533321-45533332 (-)	22,702 bp
Tssr128239	Chr14:45525302-45525320 (-)	30,718 bp
Tssr128238	Chr14:45523429-45523451 (-)	32,589 bp
Tssr128237	Chr14:45523386-45523428 (-)	32,622 bp
Tssr128236	Chr14:45522810-45522823 (-)	33,212 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24