Fbxl8 Gene Detail

Summary

• Symbol
  Fbxl8
• Name
  F-box and leucine-rich repeat protein 8
• Synonyms
  FBL8

• Feature Type
  protein coding gene
• IDs
  MGI:1354697
  NCBI Gene: 50788
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr8:105991280-105995958 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 53.04 cM, cytoband D1
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  168 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354697	protein coding gene	Chr8:105991280-105995958 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034032	protein coding gene	Chr8:107529965-107534643 (+)
A/J	MGP_AJ_G0034013	protein coding gene	Chr8:103242607-103247285 (+)
AKR/J	MGP_AKRJ_G0033939	protein coding gene	Chr8:106226612-106231290 (+)
BALB/cJ	MGP_BALBcJ_G0034006	protein coding gene	Chr8:103417765-103422443 (+)
C3H/HeJ	MGP_C3HHeJ_G0033718	protein coding gene	Chr8:106972486-106977158 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034526	protein coding gene	Chr8:111479151-111483829 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031468	protein coding gene	Chr8:96391264-96396255 (+)
CAST/EiJ	MGP_CASTEiJ_G0033044	protein coding gene	Chr8:106471450-106476078 (+)
CBA/J	MGP_CBAJ_G0033691	protein coding gene	Chr8:115076537-115081213 (+)
DBA/2J	MGP_DBA2J_G0033846	protein coding gene	Chr8:102587185-102591864 (+)
FVB/NJ	MGP_FVBNJ_G0033792	protein coding gene	Chr8:101510836-101515500 (+)
LP/J	MGP_LPJ_G0033937	protein coding gene	Chr8:107741090-107745768 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033835	protein coding gene	Chr8:118289362-118294040 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034544	protein coding gene	Chr8:106200602-106205280 (+)
PWK/PhJ	MGP_PWKPhJ_G0032745	protein coding gene	Chr8:101972305-101976937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032586	protein coding gene	Chr8:104876333-104880953 (+)
WSB/EiJ	MGP_WSBEiJ_G0033160	protein coding gene	Chr8:106853708-106858378 (+)

Homology

• Human Ortholog
  FBXL8, F-box and leucine rich repeat protein 8

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FBXL8, F-box and leucine rich repeat protein 8
  
• Synonyms
  FBL8
• Links
  HGNC:17875

  NCBI Gene ID: 55336

  neXtProt AC: NX_Q96CD0

  UniProt: Q96CD0

  
  
• Chr Location
  16q22.1; chr16:67159932-67164570 (+)  GRCh38

---

• MGI Vertebrate Homology
  Fbxl8 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: FBXL8
• Gene Tree
  Fbxl8
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  6
• Endonuclease-mediated
  2
• Targeted
  4
• Incidental Mutations
  Mutagenetix
• Find Mice (IMSR)
  20 strains or lines available

Expression

• Assay Results
  716
• Tissues
  9
• cDNA Data
  18
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase fbxl8

Sequences &
Gene Models

• All Sequences
  40
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS22595.1

• Ensembl
  ENSMUSG00000033313 (Evidence)
• NCBI Gene
  50788

Representative Sequences			Length	Strain/Species
genomic	50788	NCBI Gene Model | MGI Sequence Detail	4679	C57BL/6J
transcript	NM_015821	RefSeq | MGI Sequence Detail	1901	C57BL/6
polypeptide	Q8CIG9	UniProt | EBI | MGI Sequence Detail	374	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000007386 F-box/LRR-repeat protein 8
  (term hierarchy)
• InterPro Domains
  IPR001810 F-box domain
  IPR036047 F-box-like domain superfamily
  IPR032675 Leucine-rich repeat domain superfamily

Molecular
Reagents

• All nucleic 20

  cDNA 19

  Primer pair 1

  
  

  Microarray probesets 3

References

• Summaries
  All 26

  Developmental Gene Expression 1

  Phenotypes 5
• Earliest
  J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Fbxl8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79114	Chr8:105991288-105991329 (+)	29 bp