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Sh3bgr Gene Detail
Summary
  • Symbol
    Sh3bgr
  • Name
    SH3-binding domain glutamic acid-rich protein
  • Synonyms
    5430437A18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354740
    NCBI Gene: 50795
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:96001670-96030133 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    386 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354740
 protein coding gene Chr16:96001650-96030135 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023083
 protein coding gene Chr16:97571405-97599648 (+)
A/J MGP_AJ_G0023051
 protein coding gene Chr16:92940713-92968888 (+)
AKR/J MGP_AKRJ_G0023021
 protein coding gene Chr16:95811754-95840005 (+)
BALB/cJ MGP_BALBcJ_G0023053
 protein coding gene Chr16:93500284-93528398 (+)
C3H/HeJ MGP_C3HHeJ_G0022814
 protein coding gene Chr16:96333104-96361330 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023500
 protein coding gene Chr16:100671057-100699161 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021002
 protein coding gene Chr16:90800537-90826756 (+)
CAST/EiJ MGP_CASTEiJ_G0022333
 protein coding gene Chr16:97128615-97165736 (+)
CBA/J MGP_CBAJ_G0022783
 protein coding gene Chr16:105006108-105034543 (+)
DBA/2J MGP_DBA2J_G0022917
 protein coding gene Chr16:92828094-92857001 (+)
FVB/NJ MGP_FVBNJ_G0022891
 protein coding gene Chr16:92002312-92035280 (+)
LP/J MGP_LPJ_G0022987
 protein coding gene Chr16:97202649-97234868 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022912
 protein coding gene Chr16:109230048-109258695 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023518
 protein coding gene Chr16:96346997-96375597 (+)
PWK/PhJ MGP_PWKPhJ_G0022078
 protein coding gene Chr16:93125812-93154972 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021908
 protein coding gene Chr16:95891147-95918851 (+)
WSB/EiJ MGP_WSBEiJ_G0022384
 protein coding gene Chr16:96608231-96636322 (+)



Homology
more
  • Human Ortholog
    SH3BGR, SH3 domain binding glutamate rich protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3BGR, SH3 domain binding glutamate rich protein
  • Synonyms
    21-GARP
  • Links
    NCBI Gene ID: 6450
    neXtProt AC: NX_P55822
    UniProt: P55822

  • Chr Location
    21q22.2; chr21:39445855-39515506 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    969
  • Tissues
    227
  • cDNA Data
    29
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 50795 NCBI Gene Model | MGI Sequence Detail 28464 C57BL/6J ±  kb
transcript NM_015825 RefSeq | MGI Sequence Detail 1321 Not Specified  
polypeptide Q9WUZ7 UniProt | EBI | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000032716 SH3 domain-binding glutamic acid-rich protein
    (term hierarchy)
  • InterPro Domains
    IPR006993 SH3-binding, glutamic acid-rich protein
    IPR051033 SH3 domain-binding glutamic acid-rich protein
    IPR036249 Thioredoxin-like superfamily
  • GlyGen
    Q9WUZ7 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 33
    cDNA 30
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1918665
References
more
  • Summaries
    All 119
    Developmental Gene Expression 6
    Diseases 6
    Gene Ontology 2
    Phenotypes 90
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory