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Mapk6 Gene Detail
Summary
  • Symbol
    Mapk6
  • Name
    mitogen-activated protein kinase 6
  • Synonyms
    2610021I23Rik, D130053K17Rik, Erk3, ERK3, Mapk4, Mapk63, Prkm4, Prkm6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354946
    NCBI Gene: 50772
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75294064-75317303 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.30 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    527 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354946
 protein coding gene Chr9:75276344-75317303 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035038
 protein coding gene Chr9:75673427-75719283 (-)
A/J MGP_AJ_G0035019
 protein coding gene Chr9:73021591-73078564 (-)
AKR/J MGP_AKRJ_G0034948
 protein coding gene Chr9:74777337-74821039 (-)
BALB/cJ MGP_BALBcJ_G0035011
 protein coding gene Chr9:72707535-72748881 (-)
C3H/HeJ MGP_C3HHeJ_G0034720
 protein coding gene Chr9:75242165-75288070 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035530
 protein coding gene Chr9:77689115-77732946 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032441
 protein coding gene Chr9:72393972-72438640 (-)
CAST/EiJ MGP_CASTEiJ_G0034042
 protein coding gene Chr9:75607949-75629083 (-)
CBA/J MGP_CBAJ_G0034693
 protein coding gene Chr9:80337964-80396803 (-)
DBA/2J MGP_DBA2J_G0034852
 protein coding gene Chr9:72703130-72745356 (-)
FVB/NJ MGP_FVBNJ_G0034794
 protein coding gene Chr9:72006707-72048399 (-)
LP/J MGP_LPJ_G0034933
 protein coding gene Chr9:75925067-75968454 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034835
 protein coding gene Chr9:81434190-81479147 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035552
 protein coding gene Chr9:74930754-74972911 (-)
PWK/PhJ MGP_PWKPhJ_G0033746
 protein coding gene Chr9:72988155-73030688 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033579
 protein coding gene Chr9:75170032-75211521 (-)
WSB/EiJ MGP_WSBEiJ_G0034154
 protein coding gene Chr9:74852362-74893246 (-)



Homology
more
  • Human Ortholog
    MAPK6, mitogen-activated protein kinase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK6, mitogen-activated protein kinase 6
  • Synonyms
    ERK3, HsT17250, p97MAPK, PRKM6
  • Links
    NCBI Gene ID: 5597
    neXtProt AC: NX_Q16659
    UniProt: Q16659

  • Chr Location
    15q21.2; chr15:51952106-52067375 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    4 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show limited fetal growth, reduced serum IGF2 levels, pulmonary hypoplasia and early neonatal death. About 40% of newborns die of acute respiratory failure exhibiting delayed lung maturation, reduced sacculation, atelectasis, and impaired type II pneumocyte differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    905
  • Tissues
    160
  • cDNA Data
    152
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50772 NCBI Gene Model | MGI Sequence Detail 23240 C57BL/6J ±  kb
    transcript NM_027418 RefSeq | MGI Sequence Detail 4209 ZRU/MplStud  
    polypeptide Q61532 UniProt | EBI | MGI Sequence Detail 720 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 157
      Genomic 1
      cDNA 153
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33595, MGD-MRK-9585, MGI:105918, MGI:1346860, MGI:1917663, MGI:2441943
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory