About   Help   FAQ
Polg2 Gene Detail
Summary
  • Symbol
    Polg2
  • Name
    polymerase (DNA directed), gamma 2, accessory subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354947
    NCBI Gene: 50776
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106659079-106670363 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.01 cM, cytoband E1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354947
 protein coding gene Chr11:106659030-106670363 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019312
 protein coding gene Chr11:110102437-110114449 (-)
A/J MGP_AJ_G0019280
 protein coding gene Chr11:105400299-105411582 (-)
AKR/J MGP_AKRJ_G0019249
 protein coding gene Chr11:108540632-108553076 (-)
BALB/cJ MGP_BALBcJ_G0019254
 protein coding gene Chr11:105815375-105826461 (-)
C3H/HeJ MGP_C3HHeJ_G0019063
 protein coding gene Chr11:108837549-108849581 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019704
 protein coding gene Chr11:113502231-113515313 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017328
 protein coding gene Chr11:102668811-102680937 (-)
CAST/EiJ MGP_CASTEiJ_G0018616
 protein coding gene Chr11:109922840-109936469 (-)
CBA/J MGP_CBAJ_G0019032
 protein coding gene Chr11:118207086-118218412 (-)
DBA/2J MGP_DBA2J_G0019144
 protein coding gene Chr11:104869699-104880997 (-)
FVB/NJ MGP_FVBNJ_G0019135
 protein coding gene Chr11:104383365-104394429 (-)
LP/J MGP_LPJ_G0019214
 protein coding gene Chr11:110551653-110564309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019165
 protein coding gene Chr11:117442917-117456656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019741
 protein coding gene Chr11:109060849-109072923 (-)
PWK/PhJ MGP_PWKPhJ_G0018381
 protein coding gene Chr11:105985010-105996039 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018172
 protein coding gene Chr11:108834567-108846960 (-)
WSB/EiJ MGP_WSBEiJ_G0018667
 protein coding gene Chr11:109034812-109048000 (-)



Homology
more
  • Human Ortholog
    POLG2, DNA polymerase gamma 2, accessory subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLG2, DNA polymerase gamma 2, accessory subunit
  • Synonyms
    HP55, MTDPS16, MTDPS16A, MTDPS16B, MTPOLB, PEOA4, POLB, POLGB, POLG-BETA
  • Links
    NCBI Gene ID: 11232
    neXtProt AC: NX_Q9UHN1
    UniProt: Q9UHN1

  • Chr Location
    17q23.3; chr17:64477785-64497054 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Polg2 mouse models; 3 with human POLG2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between somite formation and turning, fail to initiate turning, lack mt-Co1 activity, and contain abnormal mitochondria with reduced mtDNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    16
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020718 Ensembl Gene Model | MGI Sequence Detail 11285 C57BL/6J ±  kb
transcript ENSMUST00000021060 Ensembl | MGI Sequence Detail 1506 Not Applicable  
polypeptide ENSMUSP00000021060 Ensembl | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012974 DNA polymerase subunit gamma-2, mitochondrial
    (term hierarchy)
  • PDB
    1G5H, 1G5I, 8F69, 8F6B
  • InterPro Domains
    IPR004154 Anticodon-binding
    IPR036621 Anticodon-binding domain superfamily
    IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
    IPR027031 Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
    IPR033731 Glycyl-tRNA synthetase-like core domain
    IPR042064 POLG2, C-terminal
  • GlyGen
    Q9QZM2 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 16
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 12
    Phenotypes 12
  • Earliest
    J:60695 Carrodeguas JA, et al., Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase. Nucleic Acids Res. 2000 Mar 1;28(5):1237-44
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory